Lecture 5: Respiratory Histology Flashcards

1
Q

What is the function of the conduction portion of the lungs?

A

Warms and filters air passing through

-no gas exchange!

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2
Q

What portions of the respiratory tract compose the conduction portion of the lungs?

A

Nasal Cavity to Terminal Bronchioles

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3
Q

What is the function of the respiratory portion of the lungs?

A

Pass air to alveoli for gas exchange

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4
Q

What portions of the respiratory tract compose the respiratory portion of the lungs?

A

Respiratory Bronchioles to Alveolar sacs

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5
Q

The wall of the larynx is reinforced by what types of cartilage?

A

Hyaline and small elastic cartilage

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6
Q

What type of epithelium is found in true vocal folds?

A

Non-keratinized stratified squamous epithelium

-protects mucosa from abrasions

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7
Q

What type of epithelium is respiratory epithelium?

A

Pseudostratified ciliated columnar epithelium

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8
Q

What is the function of respiratory epithelium?

A

Protect airway via mucus production

Transport mucus out of tract via cilia

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9
Q

What type of cells are found in respiratory epithelium?

A

Ciliated cells
Goblet cells: secrete and synthesize mucus
Basal cells

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10
Q

What are the four layers of the trachea?

A

1) Mucosa: Respiratory epithelium w/ elastic lamina propria
2) Submucosa: dense CT
3) Cartilaginous: c-shaped hyaline cartilage rings
4) Adventitia: CT that binds trachea to adjacent structure - trachealis muscle

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11
Q

What are some defining histological features of bronchi?

A
Cells short in height
Fewer goblet cells
Increased elastic fibers 
Full cartilage rings and plates
Loose/areolar CT
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12
Q

What are some defining histological features of bronchioles?

A
Transition b/t simple ciliated columnar to simple cuboidal
Few goblet cells
Increased elastic fibers
No submucosa
NO CARTILAGE
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13
Q

What are club cells?

A

Cells found in terminal bronchioles

  • prevent luminal adhesion w/ airway collapse during expiration
  • detoxifies inhaled materials
  • secretes antimicrobial peptides
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14
Q

What do respiratory bronchioles branch into?

A

Alveolar ducts –> alveolar sacs –> alveoli

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15
Q

What are some defining histological features of respiratory bronchioles?

A

Simple cuboidal
Club cells
Elastic fibers

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16
Q

What type of epithelium is found in alveolar ducts, rings, and sacs?

A

Simple squamous epithelium

17
Q

What are alveolar rings?

A

Aggregates of smooth muscle, collagen, and elastic fibers that surround alveolar ducts

18
Q

What lines alveoli sacs?

A

Type I and Type II Pneumocytes

19
Q

What type of epithelium is found in pneumocytes?

A

Simple squamous epithelium

20
Q

What is the function of Type I pneumocytes?

A

Surface for gas exchange

21
Q

What is the function of Type II pneumocytes?

A

Secrete surfactant to reduce surface tension w/in alveoli to prevent collapse during respiration

22
Q

What is the precursor for Type I and Type II pneumocytes?

A

Type II Pneumocytes

23
Q

Type I pneumocytes are ____ shaped/

Type II Pneumocytes are _____ shaped.

A

Type I Pneumocytes: Squamous (flat)

Type II Pneumocytes: Cuboidal/round

24
Q

What fluid is found in the pleural cavity?

A

Serous fluid

25
Q

What covers the pleura?

A

Mesothelium

26
Q

Describe the blood-air barrier.

A

Barrier that oxygen and CO2 have to cross in order for gas exchange to occur

27
Q

What are the components of the blood-air barrier?

A

1) Type I Pneumocytes
2) Fused basal laminae
3) Capillary endothelial cells

28
Q

Describe the physiology of asthma.

A
  • Sudden constriction of smooth muscle in bronchioles

- Infiltration by eosinophils, lymphocytes, and mast cells

29
Q

Describe the physiology of emphysema.

A

Permanent enlargement of air spaces distal to terminal bronchiole

  • significant loss of gas exchange due to decreased SA
  • destruction of alveolar walls
30
Q

Describe the physiology of pneumonia.

A

Inflammation of lung tissue

  • air spaces filled with WBC, RBC, and fibrin
  • enlarged capillaries
  • fewer air spaces