part 5

Question 1

-inhibits cyclooxygenase and has anti-inflammatory, analgesic, and antipyretic actions

Answer 1

ibuprofen (advil and motrin)

Question 2

What are the indications for ibuprofen (advil and motrin)?

Answer 2

fever
mild to moderate pain
arthritis 
generally well tolerated 
low incidence of adverse effects

Question 3

What is the safety alert for all first generation NSAIDs?

Answer 3

they are associated with an increased risk of GI bleeding that can lead to death

Question 4

• Just as effective as traditional NSAIDs in suppressing inflammation and pain
• somewhat lower risk for GI side effects

Answer 4

Second Generation NSAIDs (COX 2 inhibitors)

Question 5

-somewhat lower risk for GI side effects

Answer 5

Second Generation NSAIDs (COX 2 inhibitors)

Question 6

• can impair renal function, cause hypertension, edema

- increases risk of MI and stroke

Answer 6

Second Generation NSAIDs (COX 2 inhibitors)

Question 7

What type of inhibitor is Celeoxib (Celebrex)?

Answer 7

COX 2

Question 8

Why is Celeoxib (Celebrex) the last choice of drug for long term management of pain?

Answer 8

cardiovascular risks

Question 9

What is Celeoxib (Celebrex) used for?

Answer 9

osteoarthritis
rheumatoid arthritis 
acute pain
dysmenorrhea 
familial adenomatous polyposis

Question 10

What are the adverse effects of Celeoxib (Celebrex)?

Answer 10

dyspepsia
abd pain
renal impairment
cardiovascular impairment (stroke, MI, and other serious events)

Question 11

What are the contraindications for Celeoxib (Celebrex)?

Answer 11

pregnancy

sulfonamide allergy