Fluid compartments and solutes Flashcards
Cations
Sodium is the most plentiful in plasma
Potassium is most plentiful in muscle
Chloridehttps://www.brainscape.com/decks/9869704/cards/339852333/edit# is higher conc in plasma
High conc of K inside neutralised by porteins, nucleic acids and phosphorylated protiens
Anions in the body
Organic phosphate - ATp and phosphorylation of proteins - highly negative charge
Osmole
Tonicity
What is hypotonic
Why doesn’t a cell burst when the concentration of impermeant solutes is much higher inside cells
Because of Na/K ATPase pump
Na ions much lower inside than outisde
ATPase makes membrane effectively impermeable to Na because any Na that diffuses gets pumped out
No net movement of Na
Methods solutes use to cross membrane
Why does tissue degrade
Na/K ATPase stops functioning below 15degrees
Without circulation little O2 and little ATP to fuel pump
Na will enter cell and water will also enter as Kexits
Cells likely to swell and membranaes bleb
How do we preserve organs
Univeristy of Wisconsin solution
Reduce hypoterhmic cell swelling
Lack of Na or Cl so no influx possible
Presence of extracellular imermeant solutes (lactobionate ions, raffinose)
Presence of a macromolecuels colloid (starch)
Allopurinol and glutathione act as antioxidants to protect organs from damage form reactive oxygen species
How much plasma leaks out of blood vessels
How do molecules travel through endothelial layer
What is the colloid osmotic pressure
Higher conc of plasma proteins inside than out
What hydrostatic pressure does bloo dhave in cappilaries
What happens in oedema
What is oedema often a sign of
