16. Drugs for Depression and Anxiety Flashcards

1
Q

What are the core symptoms of depression?

A

Depressed mood
Anhedonia
Lack of energy

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2
Q

What are the treatment options for depression?

A

Mild: CBT
Moderate to severe: pharmacological
Severe resistant: electroconvulsant therapy

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3
Q

Name 2 tricyclic antidepressants

A

Imipramine

Amitriptyline

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4
Q

What is the MOA of tricyclic antidepressants?

A

Stop serotonin and NA reuptake

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5
Q

What are the side effects of tricyclic antidepressants?

A

H1 receptors: drowsiness and sedation
a1 adrenergic: postural hypotension, dizziness
Muscarinic: dry mouth, blurred vision, memory impairment
Narrow therapeutic range

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6
Q

Name 2 SSRIs

A

Fluoxetine

Sertraline

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7
Q

What is the MOA of SSRIs?

A

Selectively block serotonin uptake

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8
Q

What are the side effects of SSRIs?

A

nausea, bleeding
Headache, anxiety, insomnia, sexual dysfunction
Hyponatraemia
Serotonin syndrome

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9
Q

When are serotonin norepinephrine reuptake inhibitors used?

A

SSRIs don’t work

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10
Q

Name 3 SNRIs

A

Venlafaxine
Desvenlafaxine
Duloxetine

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11
Q

What are the side effects of SNRIs?

A

Nausea

Dose-related hypertension

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12
Q

When are monoamine oxidase inhibitors used?

A

Rarely as lethal interactions

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13
Q

What are the side effects of monoamine oxidase inhibitors?

A

With tyramine causes intracranial haemorrhage

Headache, hypotension

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14
Q

What are the active compounds in St John’s Wort?

A

Hyperforin and adhyperforin

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15
Q

What is the first line treatment for generalised anxiety disorders?

A

SSRI such as sertaline

2-3 week lag before working so co-prescribe short term benzodiazepine

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16
Q

Name a tricyclic antidepressant useful in obsession and phobia

A

Clomipramine

17
Q

What anxiety disorders are MAO-Is useful in?

A

Resistant morbid anxiety

Panic attacks

18
Q

What is the treatment for anxiety that is not improved after sertaline for 2 months?

A

Increase dose or switch to alternative SSRI or SNRI

19
Q

What are the side effects of benzodiazepines?

A

Withdrawal and dependence
Enhance depressant effects of alcohol
Resp insufficiency with underlying conditions

20
Q

Name 2 benzodiazepines that can be used as hypnotics for sleep disturbance

A

Nitrazapam

Flurazepam

21
Q

What drugs should be used in the short term vs long term treatment of sleep disturbance?

A

Short: hypnotics
Chronic: TCAs

22
Q

Name 3 classes of non-benzodiazepine hypnotics

A

Z-drugs
Anti-histamines
Melatonin

23
Q

What are the uses of b-blockers in anxiety?

A

Used for physical symptoms eg. tremor, sweating, shortness of breath

24
Q

What is the MOA of buspirone?

A

Partial agonist at 5-HT1

25
Q

What anti-convulsants are useful in anxiety?

A

Pregabalin

Sodium valproate