Classification of Hypolipidemic Drugs

Question 1

1 Classification

Answer 1

I. Preparations preventing the absorption of cholesterol in the intestines (sequestrants of bile acids)

Question 2

2 Classification

Answer 2

II. Drugs that inhibit the synthesis of cholesterol and triglycerides in the liver

Question 3

3 Classification

Answer 3

III. Drugs enhancing catabolism and excretion of atherogenic lipids

Question 4

4 Classification

Answer 4

IV. Drugs that increase the level of β-lipoproteins

Question 5

I. Preparations preventing the absorption of cholesterol in the intestines

Answer 5

1. Anion exchange resins (Kolestiramin,Colestipol)

2. Compounds of plant origin (С-sitosterol, Guarem)

Question 6

II. Drugs that inhibit the synthesis of cholesterol and triglycerides in the liver

Answer 6

1. Hydroxy-methyl-glutaryl inhibitors Coenzyme A-reductase (statins) Lovastatin, Simvastatin
2. Nicotinic acid drugs, (Nicotinic acid and its prolonged forms)
3. Derivatives of fibric acid (fibrates) (Gemfibrozil, Bezafibrat, Fenofibrate, Cyprofibrate)

Question 7

III. Drugs enhancing catabolism and excretion of atherogenic lipids

Answer 7

Acipimox

Probucol

Question 8

IV. Drugs that increase the level of β-lipoproteins

Answer 8

Eykanol

Question 9

Acipimox

Answer 9

an activator of lipoprotein lipase in adipose tissue, increases the rate of catabolism of LDL

Question 10

Probucol

Answer 10

an inhibitor of lipid peroxidation, inhibits lipid peroxidation in the vessel wall, increases the rate of LDL catabolism

Indications: hypercholesterolemia
Side effects: when taken with amiodarone, pirouette-type arrhythmias, nausea, diarrhea.
Contraindications: Q-T lengthening on ECG, myocardial ischemia,