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GENERAL PATHOLOGY > MIXED > Flashcards

MIXED Flashcards

1
Q

Examples of IgG4 related diseases-

A 
Mickulicz syndrome
Riedl’s thyroiditis
Idiopathic retroperitoneal fibrosis
Autoimmune pancreatitis
Inflammatory pseudo tumor of orbit,lungs,kidney
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2
Q

What comprises the tissue infiltrates in IgG4 related disease ?

A

IgG4 producing plasma cells
Lymphocytes predominantly T cells

Raised serum IgG4

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3
Q

What pattern of fibrosis is seen in IgG4 related syndromes ?

A

Storiform fibrosis

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4
Q

Status of calcium metabolism in each dystrophic and metastatic calcification ?

A

Dystrophic- normal calcium levels

Metastatic- deranged

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5
Q

Genetic abnormality seen in Prader Willi syndrome-

A

Deletion of paternal 15q12 chromosome and silencing of maternal allele at same position.

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6
Q

Maximum duration for TRALI to occur post blood transfusion

A

6 hours

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7
Q

Stella the granuloma is seen in

A

Cat scratch disease

BARTONELLA HENSALE infection

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8
Q

Marker in apoptosis

A

Annexin V

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9
Q

Electrophoresis pattern in

  1. Necrosis
  2. Apoptosis
A
  1. Smear pattern

2. Step ladder pattern

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10
Q

Angiofollicular lymphnode hyperplasia is also known as

A

Castleman disease

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11
Q

What is emperipolesis ?

A

Presence of hematopoietic stem cells in cytoplasm of host peripheral cells.
No damage to either of cells are seen

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12
Q

Chromosome affected in Huntington Chorea

A

Chromosome 4

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13
Q

Mention the nucleotide repeats in following disorders-

  1. Fragile X syndrome
  2. Myotonic dystrophy
  3. Huntington chorea
  4. spinocerebellar ataxia
  5. Friedrichson ataxia
A
  1. CGG
  2. CTG
  3. CAG
  4. CAG
  5. GAA
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14
Q

EFFEROCYTOSIS IS

A

Phagocytosis of apoptotic bodies by macrophages. Epithelial cells. Fibroblasts.

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15
Q

Metastasis oncogenes are

A

SNAIL

TWIST

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16
Q

Examples of type III hypersensitivity

A
  1. post streptococcal glomerulonephritis
  2. Serum sickness
  3. SLE
  4. Arthur’s reaction
  5. farmer’s lung
  6. Polyartiritis nodosa
  7. Henoch schnolen purpurin
  8. reactive arthritis
  9. Type II lepra reaction
17
Q

Most common and most severe form of lupus nephritis is

A

.type IV- diffuse lupus nephritis

18
Q

What are non-coding regulatory RNAs ?

A
  1. These are formed from non protein forming DNA part which transcript for RNA but that RNA does not translate.
19
Q

Name the anti-apoptotic and pro-apoptotic factors

A

`ANTI APOPTOTIC- ‘CL’ CONTAINING
BCL2
BCL-XL
MCL-1

Pro apototic- “A” containing
BAK. BAX

20
Q

Exposure to which chemical agent leads to

  1. Prostate cancer
  2. Lung cancer
  3. AML,ALL,CLL
A
  1. Cadmium
  2. Asbestos, Arsenic, Berillium, Chromium
  3. Benzene
21
Q

Which cell has the predominant role in ARDS ?

A

`neutrophil

22
Q

Examples of anti oxidants ?

A
  1. Superoxide dismutase enzyme
  2. Catalase
  3. iron free transferrin
  4. Copper containing ceruloplasmin
  5. Glutathione peroxidase

GENERAL PATHOLOGY (4 decks)

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