Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Z Year 2 BRS MSK > Skin infestations and infections > Flashcards

Skin infestations and infections Flashcards

1
Q

What receptors does staphyloccus have?

A

receptors that allow it to bind to fibrin that is found in abundance on wound surfaces and in dermatitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are examples of conditions staphyloccus can form?

A
  1. Panton Valentine Leukocidin
  2. Ecthyma
  3. Impetigo
  4. Cellulitis
  5. Folliculitis
  6. Staphylococcal scalded skin syndrome (SSSS) - toxic shock syndrome
  7. Superinfects other dermatoses (e.g. atopic eczema, HSV, leg ulcers)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What are different types of folliculitis?

A
  • Furunculosis

- Carbuncles

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are the difference virulence factors in steptoccous?

A
  1. Strepococcus pyogenes (β-haemolytic) attaches to epithelial surfaces via lipoteichoic acid portion of fimbriae
    2, Has M protein (anti-phagocytic) & hyaluronic acid capsule
  2. Produces erythrogenic exotoxins
  3. Produces streptolysins S and O
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What presentations can streptoccocus show?

A
  1. Ecthyma
  2. Cellulitis
  3. Impetigo
  4. Erysipelas
  5. Scarlet fever
  6. Necrotizing fasciitis
  7. Superinfects other dermatoses (e.g. leg ulcers)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is folliculitis?

A

Follicular erythema; sometimes pustular

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Is folliculitis infectious?

A

infectious or non infectious

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What type of folliculitis is associated with HIV?

A

Eosinophilic (non-infectious) folliculitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

When can there be recurrent episodes of folliculitis?

A
  1. from nasal carriage of Staphylococcus aureus

2. particularly strains expressing Panton-Valentine leukocidin (PVL)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is the treatment of folliculitis?

A
  1. Antibiotics (usually flucloxacillin or erythromycin)

2. Incision and drainage is required for furunculosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is a furuncle?

A

deep follicular abscess

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is a carbuncle?

A

deep follicular abscess

with involvement with adjacent connected follicles

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What can a carbuncle lead to?

A

more likely to lead to complications such as cellulitis and septicaemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Why do some patients develop recurrent staphylococcal impetigo or recurrent furunculosis?

A
  1. Establishment as a part of the resident microbial flora
    - Abundant in nasal flora
  2. Immune deficiency
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What immune deficiency can lead to some patients develop recurrent staphylococcal impetigo or recurrent furunculosis?

A
  1. Hypogammaglobulinaemia
  2. HyperIgE syndrome – deficiency
  3. Chronic granulomatous disease
  4. AIDS
  5. Diabetes Mellitus
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is panton valentine leukocidin (PVL)?

A
  • β-pore-forming exotoxin

* Leukocyte destruction and tissue necrosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What is the effect of panton valentine leukocidin?

A

Higher morbidity, mortality and transmissibility

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

How does PVL affect the skin?

A
  1. Recurrent and painful abscesses
  2. Folliculitis
  3. Cellulitis
    - Often painful, more than 1 site, recurrent, present in contacts
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What are the extracutaneous manifestations of PVL?

A
  1. Necrotising pneumonia
  2. Necrotising fasciitis
  3. Purpura fulminans
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What are the 5Cs to getting PVL?

A
  1. Close Contact – e.g. hugging, contact sports
  2. Contaminated items , e.g. gym equipment, towels or razors.
  3. Crowding –crowded living conditions such as e.g. military accommodation, prisons and boarding schools.
  4. Cleanliness (of environment)
  5. Cuts and grazes – having a cut or graze will allow the bacteria to enter the body
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

How do you treat PVL?

A
  1. Consult local microbiologist / guidelines
  2. Antibiotics (often tetracycline)
  3. Decolonisation
  4. Treatment of close contacts
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

How do you deconlinse PVL?

A
  1. Chlorhexidine body wash for 7 days

2. Nasal application of mupirocin ointment 5 days)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

What is pseudomonal folliculitis associated with?

A

hot tub use, swimming pools and depilatories, wet suit

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

When does pseudonomal follicultis appear?

A

1-3 days after exposure, as a diffuse truncal eruption

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

What happens during pseudonomal folliculitis?

A
  • Follicular erythematous papule

* Rarely: abscesses, lymphangitis and fever

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

How do you treat pseudomonal folliculitis?

A
  • Most cases self-limited – no treatment required.

* Severe or recurrent cases can be treated with oral ciprofloxacin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

What is cellulitis?

A
  • Infection of lower dermis and subcutaneous tissue

* Tender swelling with ill-defined, blanching erythema or oedema

28
Q

What are most cases of cellulitis? What are predisposing factors?

A
  1. Streptococcus pyogenes
  2. Staphylococcus aureus
    - Oedema is a predisposing factor
29
Q

What is the treatment of cellulitis?

A

systemic antibiotics

30
Q

What is impetigo?

A

Superficial bacterial infection, stuck-on, honey-coloured crusts overlying an erosion

31
Q

What is impetigo caused by?

A
  1. Streptococci (non-bullous)

2. Staphylococci (bullous)

32
Q

What is staphylococci impetigo caused by?

A

exfoliative toxins A and B, split epidermis by targeting desmoglein I

33
Q

Where does impetigo usually affect?

A

face (perioral, ears, nares)

34
Q

What is impetigo treated by?

A

topical +/- systemic antibiotics

35
Q

What is impetiginisation?

A
  1. Occurs in atopic dermatitis
  2. Gold crust
  3. Staphylococcus aureus
36
Q

What is ecthyma?

A

Severe form of streptococcal impetigo

37
Q

Where does ecthyma happen?

A
  • Thick crust overlying a punch out ulceration surrounded by erythema
  • Usually on lower extremities
38
Q

When does staphylococcal scalded skin syndrome (SSSS) happen?

A

Neonates, infants or immunocompromised adults

39
Q

Why does SSSS happen?

A
  1. Due to exfoliative toxin
  2. Infection occurs at distant site (ie conjunctivitis or abscess)
  3. So Organism cannot be cultured from denuded skin
40
Q

Why do neonates get SSSS?

A

kidneys cannot excrete the exfoliative toxin quickly

41
Q

What happens with neonates at SSSS?

A
  1. Diffuse tender erythema that 2. Rapid progression to flaccid bullae
  2. Wrinkle and exfoliate, leaving oozing erythematous base
42
Q

What does SSSS clinically resemble?

A

Stevens-Johnson syndrome / toxic epidermal necrolysis

43
Q

What is toxic shock syndrome?

A

Febrile illness due to Group A Staphylococcus aureus strain that produces pyrogenic exotoxin TSST-1

44
Q

What are the symptoms of toxic shock syndrome?

A
  • Fever >38.9°C
  • Hypotension
  • Diffuse erythema
45
Q

What systems are involved in toxic shock syndrome?

A 
•Involvement of ≥ systems: 
 – Gastrointestinal  
 – Muscular  
 – CNS
 - Renal 
 - Hepatic
46
Q

What else is involved in toxic shock syndrome?

A
  • Mucous membranes (erythema)
  • Hematologic (platelets <100 000/mm3)
  • Desquamation predominantly of palms and soles 1-2 weeks after resolution of erythema
47
Q

What is erythrasma due to?

A

Infection of Corynebacterium minutissimum

48
Q

What happen in erythrasma?

A

•Well demarcated patches in intertriginous areas

  • initially pink
  • Become brown and scaly
49
Q

What is pitted keratolysis?

A

Pitted erosions of soles

50
Q

What is pitted keratolysis due to?

A

Caused by Corynebacteria

51
Q

What is pitted keratolysis treated with?

A

topical clindamycin

52
Q

What is erysipeloid?

A

Erythema and oedema of the hand after handling contaminated raw fish or meat

53
Q

How quick does erysipeloid spread?

A
  • Extends slowly over weeks.

* Erysipelothrix rhusiopathiae

54
Q

What is anthrax?

A
  1. Painless necrotic ulcer with surrounding oedema and regional lymphadenopathy (with pain in lymph nodes)
  2. at the site of contact with hides, bone meal or wool
  3. infected with Bacillus anthracis.
55
Q

What is blistering distal dactylitis?

A

Rare infection caused by Streptococcus pyogenes or Staphylococcus aureus

56
Q

Who gets blistering distal dactylitis?

A

Typically - young children

57
Q

What are the signs of blistering distal dactylitis?

A
  • 1 or more tender superficial bullae on erythematous base on the volar fat pad of a finger
  • Toes may rarely be affected
58
Q

What is erysipelas?

A

Infection of deep dermis and subcutis

59
Q

What is erysipelas caused by?

A
  1. β-haemolytic streptococci

2. Staphylococcus aureus

60
Q

What are the symptoms of erysipelas?

A
  1. Painful
  2. Prodrome of malaise, fever, headache.
  3. Presents as erythematous indurated plaque with a sharply demarcated border and a cliff-drop edge
    +/- blistering
  4. Face or limb
    +/- red streak of lymphangitis and local lymphadenopathy.
    -Portal of entry must be sought (e.g. tinea pedis).
    -Systemic symptoms (fever, malaise).
61
Q

How is erysipelas treated?

A

intravenous antibiotics

62
Q

What is Scarlet fever caused by?

A

upper respiratory tract infection with erythrogenic toxin-producing Streptococcus pyogenes

63
Q

What is Scarlet fever preceded by?

A
  1. sore throat
  2. headache
  3. malaise
  4. chills
  5. anorexia
  6. fever
    - Eruption begins 12-48 hours late
64
Q

What is the eruption of Scarlet fever like?

A

-Blanchable tiny pinkish-red spots on chest, neck and axillae
-Spread to whole body within 12 hours
- Sandpaper-like texture

65
Q

What are the complications of Scarlet fever?

A
  1. otitis
  2. mastoiditis
  3. sinusitis
  4. pneumonia
  5. myocarditis
  6. hepatitis
  7. meningitis
  8. rheumatic fever
  9. acute glomerulonephritis

Z Year 2 BRS MSK (18 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions