Cystic Fibrosis Flashcards
1
Q
Name the class of CF in which delta F508 mutation occurs?
A
Class II
2
Q
Name the class of CF in which G551D mutation occurs?
A
Class III
3
Q
What type of channel is the cystic-fibrosis transmembrane conductance regulator (CFTR)?
A
A chloride channel
4
Q
Which other chloride channel does CFTR stimulate?
A
ORCC
5
Q
CFTR has a negative effect on which Na2+ transporter?
A
ENAC
6
Q
DeltaF508 causes deletion of which amino acid?
A
phenylalanine
7
Q
Mutation in G551D leads to change of Glycine into which amino acid?
A
Asparagine
8
Q
Which lung disease causing widening of airways and increased mucus secretion is common in CF?
A
Bronchiectasis
9
Q
For which class of CF mutation is Ivacaftor used?
A
Class III
10
Q
Which CF mutation does Orkambi work on?
A
DeltaF508 class II
