C. Cannabis-based medicines

Question 1

What do tricyclic antidepressants (TCAs) treat?

Answer 1

Neuropathic pain

Question 2

Give an example of a TCA

Answer 2

Amitriptyline

Question 3

What are endocannabinoids ?

Answer 3

Omega-3 and omega-6 polyunsaturated fatty acid-derived mediators

Question 4

What properties do endocanabinoids have?

Answer 4

Very hydrophobic and poorly soluble in aqueous solution

Question 5

How are endocannabinoids different to neurotransmitters?

Answer 5

• Generated on demand

- Not packed in vesicles

Question 6

What GiPCR do endocannabinoids act on ?

Answer 6

CB1 (Predominantly neuronal)

CB2 (Predominantly immune)

Question 7

What is the most famous cannabinoid metabolite?

Answer 7

THC

Question 8

What properties do TCH have ?

Answer 8

Exhibits mood altering properties

Analgesic

Partial agonist of CB1 and CB2 receptors

Question 9

Why is cannabis illegal ?

Answer 9

Quality control is a challenge. There is a mix of variation in the chemical constituent therefore cannot expect the same chemical outcomes in clinical trials

Question 10

What are the current pharmacotherapy for acute migrants ?

Answer 10

Simple analgesic

Anti-emetics

Triptans

Question 11

What are preventative migraine pharmacotherapy ?

Answer 11

Beta blockers

Amitryptaline

Botulinum toxin A

Erenumab

Question 12

How would you treat migraines?

Answer 12

Pain relief- paracetamol and cox inhibitors

Anti-emetics- metoclopramide

Triptans- sumatriptan

Question 13

How would you prevent a migraine using pharmacotherapy ?

Answer 13

Erenumab (monoclonal antibodies)

Gepants