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Pharm 3 test 4 > Anti Coagulation > Flashcards

Anti Coagulation Flashcards

1
Q

Which factors are affected by Heparin?

A

12, 11, 10, 9, 2A(thrombin)

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2
Q

Which factors are Vit K dependent?

A

2, 7, 9, 10

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3
Q

What is the prototypical parenteral anticoagulant?

A

Heparin

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4
Q

What is the prototypical oral anticoagulant?

A

Warfarin

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5
Q

What is heparins MOA?

A

Inactivation of clotting factors

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6
Q

What is warfarins MOA?

A

Decreases synthesis of clotting factors

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7
Q

What is aspirins MOA?

A

Decrease plateley aggregation

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8
Q

What is Thombolytic drugs prototype?

A

Streptokinase

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9
Q

What is streptokinases MOA?

A

Fibrinolysis

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10
Q

What is the effect that differentiates warfarin and heparin from aspirin?

A

Aspirin prevents arterial thrombus, warfarin and heparin prevent venous thrombosis

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11
Q

What is heparin a mixture of?

A

Sulfated mucopolysaccharides

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12
Q

How can heparin be administered?

A

IV or deep SQ

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13
Q

What blood test monitors heparins affects?

A

PTT

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14
Q

What are the ADEs for heparin

A

Hemorrhage
HIT
Osteoperosis
Mineralcorticoid deficiency

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15
Q

What is heparins antidote?

A

Protamine sulfate

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16
Q

Whats the in depth heparin HMW MOA?

A

Enhances the action of antithrombin III
inhibits IIa, 9, 10, 11, 12
Binds to AT-III and causes a conformational change

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17
Q

What is the in depth heparin LMWH MOA?

A

Mainly inhibits factor 10

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18
Q

What do heparins not affect?

A

Thrombin bound to fibrin or Xa bound to platelets

19
Q

Can you use heparin in pregnant patients?

A

Yes

20
Q

What is the alternative anticoagulant to switch to in the case of HIT?

A

Lepirudin or danaparoid

21
Q

What drug increases warfarin activity through inhibiting S warfarin and displace albumin bound warfarin?

A

Sulfinpyrazone

22
Q

What decreases warfarin activity?

A

Barbs, phenytoin, Vit K, and Chole’s

23
Q

What is the oral direct factor X inhibitor?

A

Rivaroxaban (Xarelto)

24
Q

What are the properties to know about rivaroxaban?

A

Does not require monitoring and has rapid onset of action

25
Q

How is Rivaroxaban metabolized?

A

CYP3A4

26
Q

What are the specific uses of Rivaroxaban?

A

Prevents embolic stroke

Prevents venous thromboembolism after knee/hip replacement

27
Q

What is the prototype drug for antiplatelets?

A

Aspirin

28
Q

Whats the broad clinical use for antiplatelelts?

A

Prevents arterial thrombus

29
Q

What are the antiplatelet drugs?

A

Aspirin,
clopidogrel, Ticlopidine
Eptifibatide
Dipyridamole

30
Q

What is aspirins moa?

A

Inhibts COX by acetylation of COX

31
Q

What is Ticlopidine and Clopidogrels MOA?

A

Blocks platelet ADP receptor and prevents activation and aggregation

32
Q

What are ticlopidine and clopidogrel both considered?

A

Pro drugs

33
Q

What activates clopidogrel?

A

CYP2C19 and Omeprazol

34
Q

What is clopidogrel used in combination with?

A

Aspirin

35
Q

What is the Glycoproetin IIb-IIIa receptor inhibitor

A

Eptifibatide
Abcizimab
Tirofiban

36
Q

What is Glycoproetin IIb-IIIa receptors function?

A

Receptor for fibrinogen and platelet adhesion

37
Q

When should fibrinolytic drugs be used?

A

Within 3 hours

38
Q

What are the fibriolytic drugs to know?

A

Stretokinase
TPA
Urokinase

39
Q

What us urokinases function?

A

Directly activates plasminogen

40
Q

What is urokinases side effects?

A

Fever, immune response

41
Q

What is TPAs MOA?

A

Activates fibrin bound plasminogen

42
Q

What is two key things to know about TPA?

A

No immune reaction

Thromboembolic stroke

43
Q

What are the drugs for bleeding disorder?

A

Vit K
Plasma fractions
Fibrinolytic inhibitors-Aminocaproic acid
Apoprotin

Pharm 3 test 4 (5 decks)

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