Resp Pharmacology

Question 1

What is the top 3 causes of death of resp conditions?

Answer 1

(1. ) Lung cancer
(2. ) COPD
(3. ) Pneumonia

Question 2

Why are inhaled medicines delivery of choice in respiratory conditions?

Answer 2

(1. ) Inhaled medications allows for delivery directly to the lungs
(2. ) Highest conc would be in the lung rather than other parts of body

Question 3

Advantages of inhaled medicines (6)

Answer 3

(1. ) Lungs are robust and can manage repeated exposure
(2. ) Large alveolar surface
(3. ) Rapid absorption
(4. ) Acts directly on lungs -> fast uptake
(5. ) Fewer drug metabolising enzymes in lungs
(6. ) Fewer systemic side effects

Question 4

List 4 delivery systems for inhaled drugs

Answer 4

(1. ) PRESSURIZED METERED-DOSE INHALERS
(2. ) SPACER DEVICES
(3. ) DRY POWDER INHALERS
(4. ) NEBULIZERS

Question 5

What is the MOA of the two types of bronchodilators

Answer 5

(1. ) Adrenergic agonists (Symp) = bronchodilation. E.g. SABA, LABA
(2. ) Anti-cholinergic (parasymp) = blocks bronchoconstriction. E.g. atropine, ipratropium bromide, tiotropium bromide

Question 6

What is an anti-inflammatory medication used in asthma + their SE?

Answer 6

(1. ) Glucorticoids, ICS
(2. ) SE:
- lone of bone density
- adrenal suppression
- cataracts, glaucoma