Biologics

Question 1

Omalizumab - indication

Answer 1

Asthma: 1) positive skin / blood test to year round allergens and 2) IgE 30-300

Chronic hives

Question 2

Omalizumab - mechanism

Answer 2

Anti IgE

Question 3

Omalizumab - trade name?

Answer 3

Xolair

Question 4

Omalizumab - black box warning?

Answer 4

Anaphylaxis 0.1 - 0.2%

Question 5

Mepolizumab - trade name?

Answer 5

Nucala

Question 6

Mepolizumab - indication

Answer 6

Asthma: eosinophil >150 at start or >300 in previous year

EGPA

Question 7

Mepolizumab - mechanism

Answer 7

Anti - IL5

Question 8

Reslizumab - trade name?

Answer 8

Cinquair

Question 9

Reslizumab - mechanism

Answer 9

Anti - IL5a subunit thereby inhibit IL-5 signaling

Question 10

Reslizumab - indication

Answer 10

Asthma: eosinophil >400

Question 11

Benralizumab - trade name

Answer 11

Fasenra

Question 12

Benralizumab - indication

Answer 12

Asthma: eosinophil > 300

Question 13

Benralizumab - mechanism

Answer 13

Anti - IL5a subunit thereby inhibit IL-5 signaling

Question 14

Dupilumab - trade name

Answer 14

Dupixent

Question 15

Dupilumab - indication

Answer 15

Asthma: eosinophil or steroid dependent

Nasal polyp

Atopic dermatitis

Question 16

Dupilumab - mechanism

Answer 16

Anti IL4Ra subunit and inhibit IL-4 and IL-13 signaling