A&P 2-test 1 Flashcards
name 3 types of tonsils
Pharyngeal
Palantine
Lingual
List 5 organs/structures associated with lymphatic/immune system
Spleen Lymph glands Tonsils Thymus Red bone marrow
SP fx 1
Blood reservior
SP fx 2
Hematopoietic center infetus
SP fx 3
Disposal center for RBC’s
SP fx 4
A place where antigens can be detected
FX 1 of lymphatic system
Network of organs and veinlike vessels that recover fluid
FX 2 of lymphatic system
Inspect it for diease agents
FX 3 of lymphatic system
Activate immune response
FX 4 of lymphatic system
Return fluid to blood stream
Where lymph system interfaces and integrates with blood
Subclavian veins
Define Lymph
- the recovered fluid
- clear colorless fluid
Define Lymphatic vessels
transport lymph
Define lymphatic tissues
composed of aggregates of lymphocytes and macrophages that populate many organs in the body
Define lymphatic organs
- defense cells are especially concentrated in these organs
- separated from surrounding organs by connective tissue capsules
3 layers of lymphatic vessesl
- Tunica interna
- tunica media
- tunica externa
RT lymphatic duct
collects lymph from rt arm, rt side of head and thorax- empties into rt subclavian vein
thoracic duct
begins as a sac called cisterna chyli- receives lymph from below diaphragm, left arm, left side of head, neck and thorax-empties into left subclavian vein
lymphatic cells
- Natural killer cells
- T lymphocytes
- B lymphocytes
- Macrophages
- Dendritic cells
- Reticular cells
Antigen presenting cells
- Macrophages
- Dendritic cells
- Reticular cells
Natural killer cells(NK)
large lymphocytes that attack and destroy bacteria, transplanted tissue, host cells infected with viruses or have turned cancerous; responsible for immune surveillance
T lymphocytes
mature in thymus
B lymphocytes
activation causes proliferation and differentiation into plasma cells that produce antibodies
Macrophages
- very large phagocytic cells of connective tissue
- develop from monocytes
- phagocytize tissue debris, dead neutrophils, bacteria, and other foreign matter
- process foreign matter and display antigenic fragments to certain t cells alerting the immune system to the presence of the enemy
- Antigen presenting cells
dendritic cells
- branched mobile APC’s found in the epidermis, mucous membranes and lymphatic organs
- alert immune system to pathogens that have breached their surface
Reticular cells
- branched stationary cells that contribute to the stroma of a lymphatic organ
- act as APC’s in the thymus
types of lymphatic tissue
- diffuse lymphatic tissue
- lymphatic nodules
diffuse lymphatic tissue
lymphocytes are scattered; prevalent in body passages open to the exterior; mucosa-associated lymphatic tissue(MALT)
lymphatic nodules
-dense masses of lymphocytes and macrophages that congregate in response to pathogens; called peyer patches in ileum.
primary lymph organs
- red bone marrow
- thymus
fx of primary lymphatic organs
site where t and b cells become immunocompetant
secondary lymphatic organs
- lymph nodes
- tonsils
- spleen
fx of secondary lymphatic organs
immunocompetant cells populate these tissues
MALT
mucosa associated lymphoid tissue-lines mucosa
GALT
gastric associated lymphoid tissue-lines gut
first line of defense against pathogens
external barriers, skin and mucous membranes
second line of defense against pathogens
several non-specific defense mechanisms-effective against a broad range of pathogens-does not depend upon prior exposure
ex of non-specific defense mechanisms
- Hyaluranic acid
- keratinized stratefied squamous epithelium
- monocytes
- complement
- interferon
third line of defense against pathogens
the immune system-results from prior exposure
ex of specific defense mechanisms
- b cells
- antibodies
acid mantle
thin film of lactic acid from sweat which inhibits bacterial growth
5 types of leukocytes in order of concentration
- neutrophils
- lymphocytes
- monocytes
- eosinophils
- basophils
mechanisms by which complement works
- enhanced inflammation
- phagocytosis by opsonization
- cytolysis
- immune clearance
mechanism by which interferons work
- alert neighboring cells
- bind to surface receptors on neighboring cells
- activates NK cells and macrophages
define chemotaxis
process by which neutrophils are attracted to areas of inflammation
Role of basophils
secrete histamine, heparin, leukotrienes and kinins
Role of eosinophils
attack parasites and toxic proteins and allergic responses
Role of fibroblasts
rebuild damaged tissue by secreting collagen, ground substance and other tissue components
role of helper t cells
secrete chemotactic factors and colony-stimulating factors
role of neutrophils
phagocytosis and digestion; wander in connective tissue killing bacteria; secrete cytokines to activate more leukocytes
define margination
the adhesion to the vessel wall of leukocytes
define diapedesis
leukocytes crawling thru gaps in the vessel walls and emigrating to the nearby tissue
define cellular immunity
employs lymphocytes to directly attack and destroy foreign cells or diseased host cells
define humeral immunity
employs anti-bodies which tag a pathogen for destruction
define t cells
participate in cellular immunity where t cells directly attack and destroy diseased or foreign cells
define b cells
function as an antigen presenting cell and morph inot plasma cell which create antibodies
fx 1 of fever
promotes interferon activity
fx 2 of fever
elevates metabolic rate and accelerates tissue repair
fx 3 of fever
inhibits reproduction of bacteria and viruses
define antipyretic
fever reducing
define plasma cells
create antibodies
Define opsonization
attachment of c3b to bacteria to make them more susceptible to phagocytosis
ave adult blood volume
5 L
fx of erythropoietin
prompts erythropoiesis
Most numerous WBC
neutrophil
normal blood ph
7.35-7.45
define Reye syndrome
serious disorder in children under 15 following an acute viral infection such as chicken pox or influenza; can be triggered by the use of aspirin
Role of erythrocytes
transport of respiratory gases
Role of lymphocytes
involved in immune response and antibody protection
Role of platlets
blood clotting
Define Pernicious anemia
inadequate Vit B12. Often found in vegetarians/vegans. Poor nutrition or lack of intrinsic factor
Define Iron-deficiency anemia
not enough iron in blood- could be not able to bind, or not being absorbed etc
Define Hemorrhagic anemia
excessive bleeding(internal or external)
Define Aplastic anemia
complete cessation of erythropoeisis
Define Hemolytic anemia
RBC’s destroyed leading to a low count
Define Sickle-cell anemia
double recessive genetic disease where the hemoglobin molecule is modified. The modified hemoglobin misfolds and changes the shape of the RBC which limits its ability to bind O2
6 elements that make up 98.5% of body weight
- Oxygen
- Carbon
- Nitrogen
- Hydrogen
- Calcium
- Phosphorus
Define ion
a particle which has lost or gained a valence electron
Four Primary Tissue types
- Epithelial
- Connective
- Nervous
- Muscular
Describe Epithelial tissue
tissue composed of layers of closely spaced cells that cover organ surfaces, form glands and serve for protection, secretion and absorption
Location of epithelial tissue
- epidermis
- inner lining of digestive tract
- liver and other glands
Describe connective tissue
tissue with usually more matrix than cell volume, often specialized to support, bind and protect organs
Location of connective tissue
- Tendons and ligaments
- cartilage and bone
- blood
Describe nervous tissue
tissue containing excitable cells specialized for rapid transmission of coded information to other cells
Location of nervous tissue
- brain
- spinal cord
- nerves
Describe muscular tissue
tissue comprised of elongated excitable muscle cells specialized for contraction
Location of muscular tissue
- skeletal muscles
- heart
- walls of viscera
Types of muscle tissue
- Skeletal
- Smooth
- Cardiac
Define organ
structure with discreet boundaries that is composed of two or more tissue types
Define tissue
a group of similar cells and cell products that arise from the same region of the embryo and work together to perform a specific structural or physiological function in an organ
Components of matrix
- fibrous proteins(collagen for ex)
- ground substance
Three primary germ layers
- ectoderm
- endoderm
- mesoderm
Role of ectoderm
gives rise to epidermis and nervous system
Role of endoderm
gives rise to mucous membrane lining, digestive and respiratory tracts, digestive glands and more
Role of mesoderm
becomes mesenchyme which becomes muscle bone and blood
Define Basement membrane
layer between epithelium and underlying connective tissue
Define Basal surface
surface of epithelial cell which faces the basement membrane
Define apical surface
surface of epithelial cell which faces away from basement membrane
Define Simple Epithelium
- one cell layer
- named by shape of cells
- all cells touch basement membrane
Define stratified epithelium
- multiple cell layers
- named by shape of apical cells
- some cells do not touch basement membrane
Type of simple epithelium
- Simple squamous
- simple cuboidal
- simple columnar
- pseudostratefied columnar
Location of simple squamous epithelium
- alveoli
- glomeruli
- endothelium
- serosa
Role of simple squamous epithelium
rapid diffusion or transport of substances; secretes serous fluid
Location of simple cuboidal epithelium
- Liver-
- thyroid
- mammary and salivary glands
- bronchioles
- kidney tubules
Role of simple cuboidal epithelium
absorption and secretion, mucous production and movement
Location of simple columnar epithelium
-lining of GI tract, uterus, kidney and uterine tubes
Role of simple columnar epithelium
absorption and secretion; secretion of mucus
Location of pseudostratified epithelium
- respiratory tract
- portion of male urethra
Role of pseudostratified epithelium
secretes and propels mucus
Types of stratified epithelium
- stratified squamous
- stratified cuboidal
- stratified columnar
- transitional epithelium
Kinds of stratified squamous epithelium
- keratinized
- nonkeratinized
define keratinized
found on skin surface;abrasion resistant
define non-keratinized
lacks surface layer of dead skin