A process, reverse transcription 27 done

Question 1

What is alternative Poly A site? What is the benefit?

Answer 1

One primary transcript can contain more than one signal sequence. This means there is more than one place for endonuclease to cleave. Depending on where the cleavage is, the gene expression can be different. This feature is why theire are differents within immunoglobulin genes (antibodies

Question 2

What is Alternative splicing?

Answer 2

When exons have more than one 3’ splice site. This will change the size of final exon - mature mRNA and ultimately protein will depend on this.

Question 3

WHich one has a bigger difference in genetic variation alternative poly A or splicing?

Answer 3

alternative splicing because this happens anywhere, while poly a only happens at 3’ end

Question 4

WHich proteins share a primary transcript, but have completely different functions?

Answer 4

calcitonin comes from the thyroid and CGRP comes from the brain. they do not have any shared sequences

Question 5

True or false: sometimes RNA receives base modifications

Answer 5

yes. bases of rna that aren’t mRNAs get modifidied. They are not damage. This occurs in snRNPs, rRNAs, tRNAs

Question 6

After transcription, which base modifications can occur for rRNA?

Answer 6

methylation, pseudouridine conversion, dihydrouridine conversion