A/protic Solvents, Leaving Groups, Nucleophiles Flashcards
Memorize compounds (34 cards)
1
Q
Water H-O-H (solvent)
A
Protic solvent
2
Q
Methanol CH3-H
A
Protic solvent
3
Q
Ethanol -OH
A
Protic solvent
4
Q
Ammonia NH3
A
Protic solvent
5
Q
Acetic Acid O=C-OH
A
Protic solvent
6
Q
Acetone C-C=O
A
Aprotic solvent
7
Q
Dimethilyformamide (DMF)
A
Aprotic solvent
8
Q
Hexamethyl-phosphoramide (HMPA)
A
Aprotic solvent
9
Q
Dimethylsulfozide (DMSO)
A
Aprotic solvent
10
Q
Acetonitrile H3C-C-=N
A
Aprotic solvent
11
Q
tetrahydrofuran (THF)
A
Aprotic solvent
12
Q
Triflate (OTF)
A
Good Leaving Group
13
Q
mesylate (OMS)
A
Good Leaving Group
14
Q
tosylate (OTS)
A
Good Leaving Group
15
Q
Iodide (I)
A
Good Leaving Group
16
Q
Bromide (Br)
A
Good Leaving Group
17
Q
Chloride (Cl)
A
Good Leaving Group
18
Q
Protonated water (R-OH2)
A
Good Leaving Group
19
Q
O-H
A
Strong Nucleophile
20
Q
R-O
A
Strong Nucleophile
21
Q
N-H2
A
Strong Nucleophile
22
Q
SH
A
Strong Nucleophile
23
Q
CN
A
Strong Nucleophile
24
Q
SCN
A
Strong Nucleophile
25
OAc
Strong Nucleophile
26
SR
Strong Nucleophile
27
I [nuc]
Strong Nucleophile
28
Br [nuc]
Strong Nucleophile
29
Cl [nuc]
Strong Nucleophile
30
H-O-H (water)
| nucleophile
Weak Nucleophile
31
R-O-H (alcohol)
Weak Nucleophile
32
N-H3 (ammonia) [nuc]
Weak Nucleophile
33
What makes a strong nucleophile?
negative charge, less stable
34
What makes a weak nucleophile?
no charge, more stable
