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FARMACOLOGIE > AB met G- spectrum > Flashcards

AB met G- spectrum Flashcards

1
Q

AB met G- spectrum

A
  • Aminoglycosiden
  • Aminocyclitols
  • Polymyxines
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2
Q

Aminoglycosiden

A
  • Streptomycine, dihydrostreptomycine
  • Neomycine
  • Gentamycine
  • Amikacine
  • Tobramycine
  • Kanamycine
  • Paromomycine
  • Apramycine
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3
Q

Werkingsmechanisme aminoglycosiden

A

Inhibitie proteïnesynthese
(50 S van ribosoom)
Bactericied, concentratieafhankelijk

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4
Q

Spectrum aminoglycosiden

A

++/////

+++++////

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5
Q

Streptomycine

A

Combinatiepreparten gebruikt tijdens de droogstand: behandeling subklinische mastitis, voorkomen van nieuwe infecties veroorzaakt door G- en G+ kiemen

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6
Q

Neomycine

A

Nefrotoxisch

Combinatieproduct: mastitis

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7
Q

Gentamicine

A

BS aminoglycose: tegen Pseudomonas, Proteus, Enterobacteriaceae

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8
Q

Amikacine

A

BS zoals gentamicine

Minder nefrotoxisch en minder gevoelig aan inactiverende enzymes

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9
Q

Tobramycine

A

BS zoals gentamicine

Uitstekend tegen Pseudomonas aeruginosa, minder nefrotoxisch, lokaal

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10
Q

Kanamycine

A

BS, niet tegen Pseudomonas

Intra-articulair

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11
Q

Paromomycine

A

Orale therapie
GIS
- bacteriën: E. coli, Salmonella
- Protozoa: Giardia, Crypto, Entamoeba

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12
Q

Apramycine

A

Oraal GIS

Parenteraal Mycoplasma

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13
Q

Toxiciteit aminoglycosiden

A

Oto- en nefrotoxisch door binding aan negatief geladen phosphatidylinositol

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14
Q

Aminocyclitols

A

Spectinomycine

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15
Q

Spectrum aminocyclitols

A

AEROBE G-: ademhalingspathogenen

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16
Q

Werkingsmechanisme aminocyclitols

A

Bacteriostatisch

GEEN oto- en nefrotoxiciteit

17
Q

Polymyxines

A

Polymyxine B, E

18
Q

Polymyxine B

A

Lokale therpapie

>< nefrotoxiciteit

19
Q

Polymyxine E

A

Oraal: speendiarre bij biggen

20
Q

Werkingsmechanisme polymyxines

A

Kationische detergenten, binding endotoxines

Absoluut bactericied, concentratieafhankelijk

21
Q

Spectrum polymyxines

A

ENKEL G-, vnl AEROBEN
//////////
+++++/++

22
Q

Toxiciteit polymyxines

A

Nefrotoxisch en neurotoxisch

FARMACOLOGIE (9 decks)

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