Abdominal Flashcards
(227 cards)
GORD
Reflux of gastric contents causing mucosal damage and weakened muscles
Prevalence of GORD
15% in adults
Common in infancy but will resolve in 12-18 months
Lifestyle risk factors of GORD
Obesity, smoking, alcohol, coffee, fatty food
Symptoms of GORD
Heartburn Acid regurgitation, unpleasant taste in back of throat Dysphagia Oesophagitis Ulceration Bloating and Belching Bad breath Waterbrash/ Acidbrash (excess salivation) Association with asthma.
Differential Diagnosis of GORD
Oesophagitis, Infection, Duodenal ulcer, gastric ulcers, Heart pain
Investigations of GORD
- Upper GI endoscopy: if oescophagitis or Barrett’s syndrome present the GORD confirmed
- Intraluminal monitoring: 24 hour pH monitoring
Management of GORD: Lifestyle choices
- Encourage weight loss, smoking cessation, raise bed head, small regular meals
- Avoid alcohol, eating before bed
Drugs to avoid in GORD
- those that slow motility: nitrates, anticholinergics, TCA
- Those that damage mucosa: NSAIDS, bisphosphonates
Drugs to treat GORD
- Alginate containing antacids e.g. gaviscon
- H2-receptor anatgonist (reduced acid production by cells) e.g. cimetidine
- PPI e.g. omeprazole, lansoprazole
- Prokinetic agents e.g. metocloperamide
Surgery for GORD
Laparoscopic Nissen Fundoplication (LNF) - surgery tightening the ring of muscle at the bottom of the oesophagus to stop acid leaking from stomach
Complications of GORD
Ulcers, Peptic stricture, Barrett’s oesophagus, Oesophagitis
Side effects of H2 receptor antagonists
Diarrhoea, headaches, rash and tiredness
Pathology of Barrett’s oesophagus
Squamous mucosa replaced by columnar mucosa
Peptic Ulcer
Breach in the mucosal lining of the stomach or duodenum
Where are gastric and duodenal ulcers most common?
Gastric ulcer- lesser curvature of the stomach
Duodenal ulcer- duodenal ampulla
Define Dyspepsia
Indigestion with pain or discomfort in the upper abdomen
Prevalence of DU and GU
Du affects 10-15% of adults and are 4x more common than GU
Who is affected in Peptic Ulcers
Common in elderly, common in females, prevalent in developing countries due to high H. Pylori infection rates
Zollinger-Ellison Syndrome
Disease in which tumours cause the stomach to produce too much acid, resulting in peptic ulcers.
What causes Zollinger-Ellison Syndrome
Gastronima, a tumour that secretes a hormone called gastrin stimulating release of gastric acid
Causes and risk factors of Peptic Ulcers
H.pylori NSAIDs, steroids, SSRIs Smoking Stress Delayed gastric emptying in GU Increased gastric emptying in PU
Which blood group is most at risk of duodenal ulcers?
O
what percentage of DU and GU does H.pylori cause?
95% of DU
80% of GU
Symptoms of peptic ulcers
Epigastric pain, N&V, bloating, weight loss, burping, reflux, back pain (suggest posterior ulcer)