Abnormalities Of Leukocytes

Question 1

Characteristics:

Answer 1

Toxic Granulation of the Neutrophils

Question 2

Associated with:

Answer 2

Toxic granulation of the neutrophils

Question 3

Characterized by the failure of the neutrophilic granuloclyte nucleus to segment (appears indented nucleus)

Answer 3

Pelger-Huet phenomenon

Question 4

Characteristics:
—Pink, red or clear inclusions found in the cytoplasm of plasma cells. Sites of antibody/immunoglobulin production; most often IgG type.

Question 5

Neutrophilic granulocytes contain coarse, dark basophilic granules in the cytoplasm

Answer 5

Alder’s bodies

Question 6

—Characterized by the presence of spherical azurophilic granules (2-5um) found in the cytoplasm.

Answer 6

Chediak-Higashi Syndrome

Question 7

—Basophilic cytoplasmic granules found in the leukocytic series of the patients with Gargoylism (Hurler’s Syndrome, Lipochondrodystrophy).

Answer 7

Reilly bodies

Question 8

Characteristics:

Answer 8

Auer Bodies

Question 9

+Associated with:

Question 10

+Associated with:

Answer 10

Auer bodies

Question 11

Characteristics:

Answer 11

Dohle bodies (Amato bodies)

Question 12

Associated with:

Answer 12

Dohle bodies (amato bodies)

Question 13

These are irregular in size inclusions, similar to Dohle Bodies, found in PMN cells, monocytes, and lymphocytes.

Answer 13

May-Hegglin anomaly

Question 14

Seen as fat-containing vacuoles in granulocytes and monocytes.

Answer 14

Jordan’s anomaly

Question 15

Characteristics:

Answer 15

Turk cell

Question 16

Associated with:

Answer 16

Turk cell

Question 17

A notched lobulated or segmented nucleus found in lymphocytes in lymphatic leukemia.

Answer 17

Reider Cells ————————

Question 18

Appear as small knob on lobe of the nucleus of the neutrophil. Found normally in females.

Answer 18

Barr Bodies

Question 19

A drumstick-like appendages attached to one of the main lobes of the nucleus of the neutrophils, eosinophils, and basophils.

Answer 19

Drumstick

Question 20

MAC (Malignancy Associated Change) seen in 88% of patient with cancer.

Answer 20

Hair cells

Question 21

Raised level of fetal hemoglobin and morphologic changes in neutrophils consisting of clumping of nuclear chromatin,
hypersegmentation, and hook-like appendages.

Answer 21

Granulocytic anomaly in D trisomy

Question 22

Tetraploid neutrophils with diploid nucleoli. Twice the size of neutrophils, round and has
two nuclei in one cell.

Answer 22

Twinning deformity

Question 23

—Response to a variety of viral and non-viral stimuli produce diverse nuclear and/or cytoplasmic changes in the lymphocytes. Often present with a lymphocytosis (↑ # lymphs).

Answer 23

Reactive/Atypical Lymphocytes

Question 24

Characteristics:
1. Irregular shape of cytoplasm and/or nucleus
2. Abundant dark blue cytoplasm; overall bigger cell
3. Cytoplasmic tags, sharp ridges; indented by red cells
4. Vacuoles in cytoplasm; increased #s of reddish granules
5. Fine chromatin pattern; nucleoli in nucleus (can resemble blasts)

Answer 24

Reactive/atypical lymphocytes

Question 25

Associated with: Many viral infections, e.g. Epstein-Barr virus (EBV), cytomegalovirus (CMV), viral hepatitis Drug reactions or non-viral stimuli...e.g., toxoplasmosis The lymphs seen in healthy children may appear somewhat reactive as compared to adult lymphs.

Answer 25

Reactive/Atypical lymphocytes

Question 26

Aggregates of Russell bodies in a plasma cell are called

Answer 26

Mott cells or grape cells

Question 27

Toxic granulation of the neutrophils is often present with

Answer 27

Dohle bodies or vacuolization

Question 28

Auer rods are composed of

Answer 28

Fused primary granules

Question 29

Large dohle bodies are present in

Answer 29

May hegglin anomaly