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Intro to BB (lect prelims) > ABO grouping > Flashcards

ABO grouping Flashcards

1
Q

discovered the ABO grouping

A

Dr. Karl Landsteiner

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2
Q

ABO inheritance follows __ genetics

A

mendelian genetics

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3
Q

ABO gene is located on what chromosome and consist of __ exons

A

chromosome 9 (7 exons)

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4
Q

O gene is considered an __ and is an autosomal recessive trait

A

amorph

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5
Q

formation of ABH antigen develops at?

A

second month of fetal life

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6
Q

ABO, Hh, Se genes code for the production of ___ that adds sugar to the precursor

A

glucosyltransferase

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7
Q

precursor substance of ABH

A

glycan/paragloboside

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8
Q

RBC ABO antigens are constructed from what precursor

A

type 2

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9
Q

H gene is located at chromosome?

A

chromosome 19

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10
Q

rare, doesnt have H antigen
also called bombay phenotype

A

hh

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11
Q

H gene codes for ___ that adds sugar fucose to the terminal galactose type 2

A

1,2 fucosyl transferase

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12
Q

Se gene codes for ___ that adds sugar fucose to the terminal galactose type 1

A

1, 2 fucosyl transferase (FUT2)

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13
Q

A gene codes for ___ which joins the sugar __ to the terminal galactose of an H antigen

A

1, 3 N-acetylgalactosaminyl transferase
N-acetyl-D-galactosamine

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14
Q

B gene codes for __ which adds galactose of the terminal galactose of an H antigen

A

1,3 galactosyl transferase

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15
Q

group O01 results from what type of polymorphism

A

single deletion

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16
Q

group O results form?

A

mutation in A or B gene

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17
Q

rbc membrane proteins carry over __ A B or H antigens mostly foun on the major integral protein __

A

2x10^6 major intergal membrane protein 3

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18
Q

blood group found usually in africans, americans, and asians

A

group B (20% black 11% white)

19
Q

most common blood group found in asians

A

group A and O (40-45% whites 50% blcks)

20
Q

rarest blood group

A

AB

21
Q

basic antigenic material of ABO and is found in greatest concentration on the RBCS of O individuals

A

H antigen

22
Q

what antiserum does H antigen can be detected?

A

Ulex europeus

23
Q

ABH antigens are found in secretions of people with the __ phenotype

A

Se or FUT2 gene

24
Q

secretes A, B, H antigen in saliva, sweat, urine

A

SeSe or Sese

25
Q

non-secretor genes

A

sese

26
Q

determination for secretor genes

A

ABH test on saliva

27
Q

bombay phenotype is the inheritance of hh gene therefore no __

A

H susbstance

RBCs does not react with anti-H lectin

28
Q

bombay is first reported by __ in 1952

A

Dr. Bhende

29
Q

what does it mean by bombay?

A

can inherit A or B genes but has no H substance, therefore no ABH antigens

30
Q

bombay was caused by a mutation in what gene

A

FUT1 gene

31
Q

FUT1 gene produces what gene

A

silenced gene

32
Q

bombay serum contains anti-?

A

anti-A, anti-B, anti-AB

33
Q

an igM that reacts at 37C

A

anti-H

34
Q

Pphenotypes where rbcs completely lack H antigens or have only small amounts of H antigen present

A

para-bombay phenotypes

35
Q

what phenotype? anti-H produced is weaker but still reactive at 37C

A

para-bombay

36
Q

inheritance of A1 gene elicits production of high concentration of?

A

3-N-acetylgalactosaminyltransferase

37
Q

A1 creates about ___ antigen sites on adult RBC

A

810 000 - 1 170 000

38
Q

A2 results from what mutation

A

single base substituion

39
Q

reagent used to differentiate A1 and A2

A

dolichos biflorus

40
Q

ABO antibodies develops at __ and peaks at __

A

develops at 3-6 months after birth
peaks at 5-10

41
Q

cold antibody also present in plants and other animals or lectins

A

ABO antibodies

42
Q

anti-__ created by group O individuals

A

anti-AB

43
Q

anti-__ an autoantibody

A

anti-H

Intro to BB (lect prelims) (9 decks)

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