ABO grouping

Question 1

discovered the ABO grouping

Answer 1

Dr. Karl Landsteiner

Question 2

ABO inheritance follows __ genetics

Answer 2

mendelian genetics

Question 3

ABO gene is located on what chromosome and consist of __ exons

Answer 3

chromosome 9 (7 exons)

Question 4

O gene is considered an __ and is an autosomal recessive trait

Answer 4

amorph

Question 5

formation of ABH antigen develops at?

Answer 5

second month of fetal life

Question 6

ABO, Hh, Se genes code for the production of ___ that adds sugar to the precursor

Answer 6

glucosyltransferase

Question 7

precursor substance of ABH

Answer 7

glycan/paragloboside

Question 8

RBC ABO antigens are constructed from what precursor

Answer 8

type 2

Question 9

H gene is located at chromosome?

Answer 9

chromosome 19

Question 10

rare, doesnt have H antigen
also called bombay phenotype

Answer 10

hh

Question 11

H gene codes for ___ that adds sugar fucose to the terminal galactose type 2

Answer 11

1,2 fucosyl transferase

Question 12

Se gene codes for ___ that adds sugar fucose to the terminal galactose type 1

Answer 12

1, 2 fucosyl transferase (FUT2)

Question 13

A gene codes for ___ which joins the sugar __ to the terminal galactose of an H antigen

Answer 13

1, 3 N-acetylgalactosaminyl transferase
N-acetyl-D-galactosamine

Question 14

B gene codes for __ which adds galactose of the terminal galactose of an H antigen

Answer 14

1,3 galactosyl transferase

Question 15

group O01 results from what type of polymorphism

Answer 15

single deletion

Question 16

group O results form?

Answer 16

mutation in A or B gene

Question 17

rbc membrane proteins carry over __ A B or H antigens mostly foun on the major integral protein __

Answer 17

2x10^6 major intergal membrane protein 3

Question 18

blood group found usually in africans, americans, and asians

Answer 18

group B (20% black 11% white)

Question 19

most common blood group found in asians

Answer 19

group A and O (40-45% whites 50% blcks)

Question 20

rarest blood group

Answer 20

AB

Question 21

basic antigenic material of ABO and is found in greatest concentration on the RBCS of O individuals

Answer 21

H antigen

Question 22

what antiserum does H antigen can be detected?

Answer 22

Ulex europeus

Question 23

ABH antigens are found in secretions of people with the __ phenotype

Answer 23

Se or FUT2 gene

Question 24

secretes A, B, H antigen in saliva, sweat, urine

Answer 24

SeSe or Sese

Question 25

non-secretor genes

Answer 25

sese

Question 26

determination for secretor genes

Answer 26

ABH test on saliva

Question 27

bombay phenotype is the inheritance of hh gene therefore no __

Answer 27

H susbstance RBCs does not react with anti-H lectin

Question 28

bombay is first reported by __ in 1952

Answer 28

Dr. Bhende

Question 29

what does it mean by bombay?

Answer 29

can inherit A or B genes but has no H substance, therefore **no ABH antigens**

Question 30

bombay was caused by a mutation in what gene

Answer 30

FUT1 gene

Question 31

FUT1 gene produces what gene

Answer 31

silenced gene

Question 32

bombay serum contains anti-?

Answer 32

anti-A, anti-B, anti-AB

Question 33

an igM that reacts at 37C

Answer 33

anti-H

Question 34

Pphenotypes where rbcs completely lack H antigens or have only small amounts of H antigen present

Answer 34

para-bombay phenotypes

Question 35

what phenotype? anti-H produced is weaker but still reactive at 37C

Answer 35

para-bombay

Question 36

inheritance of A1 gene elicits production of high concentration of?

Answer 36

3-N-acetylgalactosaminyltransferase

Question 37

A1 creates about ___ antigen sites on adult RBC

Answer 37

810 000 - 1 170 000

Question 38

A2 results from what mutation

Answer 38

single base substituion

Question 39

reagent used to differentiate A1 and A2

Answer 39

dolichos biflorus

Question 40

ABO antibodies develops at __ and peaks at __

Answer 40

develops at **3-6 months** after birth peaks at **5-10**

Question 41

cold antibody also present in plants and other animals or lectins

Answer 41

ABO antibodies

Question 42

anti-__ created by group O individuals

Answer 42

anti-AB

Question 43

anti-__ an autoantibody

Answer 43

anti-H