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ABO/Rh Flashcards

(60 cards)

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1
Q

most important antigen group for transfusion and transplant

A

ABO Blood group

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2
Q

exception when there won’t be rejection

A

incompatible bone marrow with high immunosuppressive drugs

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3
Q

forward grouping

A

detect ABO antigen on patient RBCs

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4
Q

reverse grouping

A

detect ABO antibodies in patient serum

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5
Q

if back typing weak

A

add additional patient serum and incubate longer at RT

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6
Q

abo antibodies are

A

naturally occuring

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7
Q

anti-A and anti-B class

A

IgM

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8
Q

ABO antibodies detectable

A

3-6 months are birth

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9
Q

Anti-A,B occur naturally in

A

group O

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10
Q

anti-A, B

A

predominantly IgG

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11
Q

abo locus

A

chromsome 9

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12
Q

fucosyltransferase

A

produces H antigen to type 2 precursor chains

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13
Q

FUT2 produces

A

soluble H antigen will end up in secretions and body fluids and fixes fucose to type 1 precursor

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14
Q

type 1

A

B 1-3

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15
Q

type 2

A

b 1-4

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16
Q

A

A

N-acetylgalactosaminyl transferase

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17
Q

B

A

galactosaminyl transferase

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18
Q

AB

A

N-acetylgalactosaminyl transferase and galactoasminyl transferase

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19
Q

most amount of H

A

A2

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20
Q

ABH expression complete at

A

2-4 age

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21
Q

ABH antigens in

A

body fluids and secretions (secretor trait)

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22
Q

FUT2 modifies type 1 precursor chains to form

A

soluble H antigen

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23
Q

non secretor

A

Le a

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24
Q

secretor

A

Le b

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25
agglutinate with A1
dolichos biflorus
26
agglutinates cells with H antigen
ulex europaeus
27
bandeiraea simplicifolia
agglutinated cells with B antigen
28
produce less antigen
A2
29
subgroups of A
very weak front typing with anti-A or unexpected A cells in back typing
30
if suspect an A2 use
A1 lectin and will show no reactivity
31
B3 is most common subgroup of B
shows mixed field agglutination
32
hh genotype caused by
lack of H, lack fucosyltransferase = no ABO genes
33
bombay can only receive
bombay
34
parabombay
-H expression is near 0 dysfunctional FUT1 with functional FUT2
35
dysfunctional FUT1 with functional FUT2
very small A, B, H; makes anti-H unless AHG phase
36
dysfunctional FUT but no FUT2
very small amounts of ABH on RBCs, none in secretions
37
silenced FUT1 active FUT2
make soluble ABH antigens ; make anti- IH
38
2nd most important blood group following ABO
Rh system
39
Rh reside of
proteins
40
Rh antigens are
not naturally occuring; require foreign RBC's
41
Rh null
no Rh antigens (-1,-2,-3,-4,-5)
42
f antigen
present on cells for homozygous for ce
43
G antigen
present on all C positive and many D positive cells
44
Cw antithetical to
near universal antigen MAR
45
partial D/ mosaic D
-missing or incomplete epitopes for D antigen -these people can make anti-D against missing portions of antigen so = Rh -
46
weak d
express d weakling but it still there so Rh +
47
positional effect C: D
D antigen is complete just reduced, so receive D + units
48
Rh antibodies class
IgG
49
Rh donors
weak d testing done on every unit, but be done all the way through
50
Rh patients
if typed initially as weak d, DO NOT have to follow all the way through
51
delayed hemolytic transfusion reactions
caused by giving a patient a unit of blood that is positive for an antigen and they have an anamnestic response to that antigen (extravascular lyse)
52
HDFN
severve from Rh antibody Rh antigens well developed on fetal cells and cross placenta
53
rhogam given to what type mother
negative
54
Rh deficiency syndrome
lack all Rh proteins on RBCs
55
regulator type
RhAG required to traffic RhD and RhCE to cell surface RhAG mutated- none produced
56
amorphic type
mutation in RhCE and deletion of RhD in lack of Rh proteins
57
symptoms of Rh def
hemolytic anemia, decrease serum haptoglobin, slight elevation in bili
58
Rh null patients can develop
anti-Rh29 "total Rh" reacts will all Rh antigens
59
Rh Mod
partial suppression of Rh genes caused by mutations in RhAG protein
60

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