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Immunohematology (Blood Bank) > ABO system > Flashcards

ABO system Flashcards

1
Q

Sugar that attaches to H antigen to make A antigen

A

N-acetylgalactosamine

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2
Q

Sugar that attaches to H antigen to make B antigen

A

D-galactose

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3
Q

Sugar that attaches to H antigen to make O blood type

A

O blood type is H antigen with no additional sugars attached.

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4
Q

Percentage of population that are secretors

A

80% are SeSe or Sese (secretors)

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5
Q

Bombay phenotype

A

Rare phenotype. Individuals produce no H substance.

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6
Q

Anti-A1 lectin

A

Dolichos biflorus

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7
Q

Anti-H lectin

A

Ulex europeus

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8
Q

Forward grouping

A

Use of commercial antisera with known antibodies to test unknown cells. If reaction of cells is positive, then the antigen corresponding to the known antibody is present.

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9
Q

Reverse grouping

A

Use of commercial red blood cells with known antigens to test unknown serum or plasma. If reaction is positive, then the antibody corresponding to the known antigen is present.

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10
Q

Color of reagent and product label of anti-A reagent.

A

Blue

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11
Q

Color of reagent and product label of anti-B reagent.

A

Yellow

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12
Q

Which antiserum will agglutinate with both A and B red blood cells?

A

Anti-A,B

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13
Q

Discovered the ABO blood group system in 1900

A

Karl Landsteiner

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14
Q

Immunodominant sugar of the H antigen

A

L-fucose

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15
Q

Genotype of secretors

A

SeSe or Sese. The secretor gene must be present on at least one chromosome for the secretory property to be expressed.

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16
Q

Presence of H antigen by ABO group - (which has the most and the least H antigen)

A

Type O has the most and type A1B the least. The order of H antigen expression from most to least:
O-A2-A2B-B-A1-A1B

17
Q

Approximate percentage of individuals who are secretors

A

80%

18
Q

Percentage of group A individuals who are subgroup A1

A

80%

19
Q

Temperature of reactivity of most ABO antibodies

A

4 degrees C. ABO antibodies are typically IgM. IgG and IgA isotypes do exist and may cause HDFN (hemolytic disease of the fetus and newborn) and HTR (hemolytic transfusion reactions).

20
Q

Universal donor of red blood cells

A

Group O

21
Q

Universal recipient of red blood cells

A

Individuals of Group AB

22
Q

Universal donor of plasma

A

Group AB individual

23
Q

Universal recipient of plasma

A

Group O individual

Immunohematology (Blood Bank) (9 decks)

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