ABX Flashcards
(18 cards)
B-Lactam drug catergories
PCN, Cephalosporins, Carbapenems, Monobactams
PCNs
- PCN (G, VK)
- AminoPCN
- Ampicillin
- Amoxicillin - Antistaph
- Niafcillin, Oxacillin, Dicloxacillin - Antipseudamonal
- Piperacillin
-Ticarcillin
Which PCN does NOT cover Strep/enterococcus?
Ticarcillin (+clavulanate)
Which PCNs cover the G- rod obligate anaerobe B. Fragilis?
+ beta-lactamase drugs
(sulbactam, clavulanate, Tazobactam)
Unasyn
Augmentin
Piperacillin + Tazobactam
Ticarcillin + Clavulanate
B. Fragilis bacteria characteristics?
What does it cause?
Gram - rod; obligate intracellular anaerobe
PID, intra-abdominal infxn, pulm infxn, periodontal DZ
What G- do aminopcns cover?
Neisseria (diplococci)
E. Coli & proteus (enterobacteria; rods, lactose +, fermenters
H. Influenzae (coccobacilli, respiratory)
What PCN has a dose related neutropenia?
Which PCN may increase LFTs?
a) Niafcillin
b) oxacillin
Which PCNs do not have any renal dosing noted?
PCN G/VK
Dicloxacillin
What is the renal dosing
a) ampicillin
b) amoxicillin
Ampicillin RD <50
Amoxicillin RD <30
What is the PCN DOC for susceptible enterococci?
Aminopcn
What is the PCN DOC for Listeria w/ meningitis?
Ampicillin
What PCN have added STAPH coverage AND improved G-?
Aminopcns + B-lactamase inhibitors
Which PCNs have more and the most Broad spectrum coverage?
Which PCN has some activity against ESBL G- rods (e.coli, proteus, Klebsiella)
a) more = Piperacillin
most = piperacillin + Tazobactam
b) ESBL activity = pip/tazo
PCN side effects?
GI, diarrhea, rash/allergy rxn, seizures with accumulation
Which PCN covers treponema Palliidium?
PCN G/VK
What are the 1st gen cephalosporins?
G+ coverage
G- coverage
Cefazolin
Cephalexin
G+: excellent MSSA/E & Strep
G-: weak E.coli, Proteus, Klebsiella
What are the 2nd gen group a cephalosporins?
Their coverage?
Cefuroxime, Cefprozil, Cefaclor
G+: Good MSSA/A; strep
G-: E.coli, proteus, Klebsiells, H. influenzae
Anaerobes: mouth anaerobes
What are the 2nd gen group b “cephamycins” and their coverage?
