Abx

Question 1

Prophylaxis

Answer 1

Prevention of disease- taking abx before surgery or procedure to prevent infection

Question 2

Empiric therapy

Answer 2

Treatment with abx before the specific organism has been identified

Question 3

Definitve therapy

Answer 3

abx use based on identified organism

Question 4

colonization

Answer 4

growth of microorganisms in a particular body site

Question 5

infection

Answer 5

disease caused by microorganism

Question 6

Contamination

Answer 6

introduction of pathogens into normally clean and sterile environment

Question 7

bactericidal

Answer 7

capable of killing bacteria

Question 8

bacteriostatic

Answer 8

inhibition or retardation of growth of bacteria with out their destruction

Question 9

bactericidal drugs

Answer 9

Kill bacteria- peniciilans

Question 10

Clavulanic acid

Answer 10

Beta lactam agonist- restores function of antibiotic by addressing resistance

Question 11

Aminoglycosides- Mech of action

Answer 11

Ribosomal protein synthesis inhibitor- bacteriostatic- can be cidal with increased concentration

Question 12

Aminoglycosides- Types

Answer 12

End in mycin- gentomycin, streptomycin, neomycin

Question 13

Aminoglycosides- Spectrum of activity

Answer 13

Gram -Including Pseudomoas aerug- severeSynergistic with beta lactam for gram +

Question 14

Beta Lactams

Answer 14

Penicillin, Cephalosporins, carbapenem & vancomycin

Question 15

Penicillin- Mech of action

Answer 15

Inhibit cell wall synthesis leads to cell lysis

Question 16

Penicillins- Names

Answer 16

End in cillin- penicillin G, ampicillin, amoxicillin

Question 17

Penicillins- Uses

Answer 17

Gram +Streptococci

Question 18

Peinicillin G, VK

Answer 18

Drug of choice for N Meningitis, syphilis

Question 19

Ampicillin & amoxicillin

Answer 19

Gram +Extended spectrumRespiratory infectionsStreptococci, enterococci

Question 20

Cephalosporins- mech of action

Answer 20

Beta lactam antibiotics- inhibit cell wall synthesis

Question 21

1st generation cephalosporins

Answer 21

cephlexn, cefazolin

Question 22

1st generation cephalosporin- spectrum of activity

Answer 22

Gram +: Strept, MSSA some Gram -: E.coli, Klebisselaskin & resp infections

Question 23

2nd generation Cephalosporin- spectrum of activity

Answer 23

Gram +: Strept, MSSAGram - : Good coverage- B fragilis

Question 24

2nd generation cephalosporin- drug names

Answer 24

cefuroxime, cefotetan, ceforitin

Question 25

3rd generation cephalosporins- drug names

Answer 25

ceftriaxone, cefotaxime, ceftzidime

Question 26

3rd generation cephalosporins- spectrum of activity

Answer 26

Resp & serious infectionsPenetrates CSFGram +: Strept, MSSAGram - Very good- pseudomonas

Question 27

4th generation cephalosporins- drugs

Answer 27

cefepime

Question 28

4th generation cehpalosporins- spectrum of activity

Answer 28

Gram +: Strept, MSSAGram - excellent- through Pseudomondas

Question 29

Monobactam- mechanism of action

Answer 29

Disrupt cell wall synthesis- baceriacidal

Question 30

Monobactam- drug

Answer 30

aztreonam

Question 31

Monobactam- spectrum of activity

Answer 31

Gram -Up to pseudomondas

Question 32

Carbapenem- mech of action

Answer 32

Beta lactam- disrupt cell wall synthesis

Question 33

Carbapenem- Drugs

Answer 33

End in penem- imipenem

Question 34

Vancomycin- Mech of action

Answer 34

Inhibits cell wall synthesis- beta lactam

Question 35

Vancomycin- Spectrum of activity

Answer 35

Drug of choice for MRSAStrept, Staph, EnteroNo Gram -

Question 36

Macrolides- drugs

Answer 36

erythromycin, clarithromycin, azithromycin

Question 37

Macrolides- Mech of activity

Answer 37

Ribosomal inhibition- bacteriostatic

Question 38

Macrolide- Spectrum of activity

Answer 38

Gram +Chlamydia & syphallisAtypical respiratory infections: Legionella, pneumoniae

Question 39

Tetracyclines- Drugs

Answer 39

end in cycline- doxycycline, tetracycline, mincycline

Question 40

Tetracycline- Mech of action

Answer 40

Ribosomal protein synthesis inhibitor- bacteriostatic

Question 41

Tetracycline- spectrum of activity

Answer 41

Gram + strept & MSSAWeak Gram -A typical respiratory infections

Question 42

Quinolones- Drugs

Answer 42

"floxacin"ciprofloxacin, norfloxacin

Question 43

Quinolones- Mech of action

Answer 43

Inhibit DNA synthesis- bacteriostatic

Question 44

Sulfa Drugs

Answer 44

Trimethoprim-sulfamethoxazole

Question 45

Sulfa- Mech of action

Answer 45

Inhibit folic acid synthesis- formation of essential cofactor- bacteriostatic

Question 46

Sulfa- Spectrum of activity

Answer 46

Gram + Strept, MSSAGram - Enterobacteriacae

Question 47

Anaerobic agents

Answer 47

Clindamycin, metronidazole, chloramphenicol

Question 48

Anaerobic- mech of action

Answer 48

Inhibition of ribosome- bacteriostatic