ABX

Question 1

What are the 3 sites of ABX action?

Answer 1

Cell wall
Ribosomes
DNA

Question 2

Which ABX types target the ribosomes?

Answer 2

Aminoglycosides (Gent)
Tetracyclines (-cyclines)
Macrolides (-mYcin)
Chloramphenicol
Clindamycin

Question 3

Which ABX types target the DNA?

Answer 3

Fluoroquinolones (-floxacin)
Metranidazole
Trimithoprim/septrin (co-trimoxazole)

Question 4

Which ABX types target the cell wall?

Answer 4

Beta lactams

Glycopeptides (Vanc + Teic)

Question 5

What are the subtypes of beta-lactams?

Answer 5

Penicillins
Carbapenems
Cephalosporins

Question 6

What class is meropenem?

Answer 6

Carbapenem

Question 7

What class is Tazocin?

Answer 7

Penicillin (Piperacillin + B lacatamase inhibitor)

Question 8

What class is Cefepime?

Answer 8

Cephalosporin

Question 9

What class is Ertapenem?

Answer 9

Carbapenem

Question 10

What class is Cefotaxime?

Answer 10

Cephalosporin

Question 11

Which class of ABX has multiple generations?

Answer 11

Cephalosporin (Beta-lactam)

Question 12

What class of antibiotic is Vancomycin?

Answer 12

Glycopeptide

Question 13

What do the Glycopeptides target?

Answer 13

The cell wall

Question 14

Give two examples of glycopeptides

Answer 14

Vanc + Teic

Question 15

Give an example of an aminoglycoside

Answer 15

Gentamicin

Question 16

Give 2 examples of tetracyclines

Answer 16

Doxycycline

Tetracycline

Question 17

What class of antibiotic is Erythromycin?

Answer 17

Macrolide

Question 18

What class of antibiotic is Clindamycin?

Answer 18

Its own type (Lincosamide)

Question 19

What class of antibiotic is Chloramphenicol?

Answer 19

Its own type

Question 20

What class of antibiotic is Clarithromycin?

Answer 20

Macrolide

Question 21

What class of antibiotic is Azithromycin?

Answer 21

Macrolide

Question 22

Give 3 examples of Macrolides.

Answer 22

Erythromycin
Clarithromycin
Azithromycin

Question 23

Which two types of commonly used antibiotic have their own classes which target protein synthesis?

Answer 23

Clindamycin

Chloramphenicol

Question 24

Give two examples of Fluoroquinolones?

Answer 24

Moxifloxacin
Levofloxacin
Ciprofloxacin

Question 25

What type of antibiotic is Ciprofloxacin?

Answer 25

A fluoroquinolones

Question 26

What class of antibiotic is Metronidazole?

Answer 26

Its own subtype which targets DNA synthesis

Question 27

What class of antibiotic is Septin, what is it's generic name and what is it made of?

Answer 27

It's own class - co-trimoxazole - trimethoprim and sulfamethoxazole.

Question 28

What spectra of bacteria do penicillins cover?

Answer 28

Fluclox - Staph (fluclox is large so avoids B-lactamase), Strep (mildly effective) Other simple penicillins (Benzylpenicliin + Amoxicillin) - Gram +ve, scattered gram -ve The combined penicillins (Co-amox + Tazocin) - Gram +ve + Gram -ve cover

Question 29

What spectra of bacteria do Carbapenems cover?

Answer 29

Good gram +ve and gram -ve cover

Question 30

What spectra of bacteria do Cephalosporins cover?

Answer 30

Staph + Step + some gram -ve cover

Question 31

What are the main gram +ve organism classes?

Answer 31

Enterococcus (a type of streptococcus), staphylococcus (MRSE + MSSA) and streptococcus

Question 32

Which antibiotics can not be used with MRSA?

Answer 32

All of the beta-lactams (Penicillins, carbapenems and cephalosporins)

Question 33

Which antibiotics can be used for pseudomonas?

Answer 33

Meropenem, Tazocin, Gentamicin, Ciprofloxacin

Question 34

Which antibiotic subclasses are target protein synthesis and what bacteria do they target?

Answer 34

``` Aminoglycosides (Gent) Tetracyclines (-cyclines) Macrolides (-mYcin) Chloramphenicol Clindamycin ``` Varied gram +ve and -ve cover

Question 35

What types of bacteria does ciprofloxacin target?

Answer 35

Good gram -ve cover

Question 36

What types of bacteria does Metronidazole cover?

Answer 36

C.diff