Acetylcysteine Flashcards
1
Q
What is the trade name for acetylcysteine?
A
Mucomyst
2
Q
What are the three MOAs of acetylcysteine?
A
- replenishes glutathione stores
- serves as glutathione substitute
- enhances sulfate conjugation of acetaminophen
3
Q
What is the PO loading dose of acetylcysteine?
A
140mg/kg
4
Q
What is the PO maintenance dosing of acetylcysteine?
A
70mg/kg q4h for 17 doses (72 hours)
5
Q
What is the IV loading dose of acetylcysteine?
A
150mg/kg in 200ml D5W over 1 hour
6
Q
What is the IV maintenance dose of acetylcysteine?
A
50mg/kg in 500ml D5W over 4 hours and then 100mg/kg in 1 liter D5W over 16 hours (21 hours total)
7
Q
What is the pregnancy class of acetylcysteine?
A
B
8
Q
What is the most common drug reaction to acetylcysteine?
A
Hypersensitivity reaction (stop infusion, switch to PO or slow infusion rate)
