Acid-Base Flashcards
Where does the largest contribution of metabolic acids arise from?
Oxidation of carbohydrates (glucose) to produce carbon dioxide
The bicarbonate buffer system accounts for ______ of the total buffering capacity of blood
> 50%
________ is a weaker acid (better proton acceptor) than ________
Deoxygenated hgb; oxyhemoglobin
In the systemic capillaries, dissociation of _____ to _____ facilitates the binding of H ions produced by the dissociation of carbonic acid
Oxyhemoglobin; deoxyhemoglobin
What happens to the hemoblobin buffering system in the pulmonary circulation?
Deoxyhemoglobin converts to oxyhemoglobin which facilitates the release of H ions
Approximately 75% of all buffering of body fluids occurs in the cell by what?
Proteins
The phosphate buffering system is especially important where?
In renal tubules (where phosphate is concentrated)
_________ is a very important intracellular buffer bc it is the most abundant intracellular anion
Phosphate
HCL + NaHCO3 —> ?
H2CO3 + NaCl
The most important mechanism of acid removal
Ventilation
The day-to-day renal contribution to acid-base regulation is directed toward the conservation of _____ and the excretion of _____
Bicarbonate; H ions
Typically, the anion that follows changes in the concentration of bicarb ions is ______
Chloride
CNS excitability may manifest as ______. A/w ?
Seizures, tetany. Alkalosis
Decreased alveolar ventilation results in increased dissolved CO2 which in turn leads to?
Formation of carbonic acid and H ions
Increasing muscle weakness after reversed neuromuscular block
Recurarization
