Activators of cAMP pathway

Question 1

Forskolin

Answer 1

Natural product that activates adenyl cyclase

Question 2

Caffeine

Answer 2

Inhibit cAMP phosphodiesterase, which degrades cAMP, thus enabling higher levels of cAMP than otherwise would be had

Question 3

Pertussis toxin

Answer 3

Increase cAMP levels by inhibiting Gi to its GDP form.
Leads to an increase in adenylyl cyclase activity, thereby increasing cAMP levels, which can lead to an increase in insulin and therefore hypoglycaemia

Question 4

Cholera toxin

Answer 4

Increase cAMP levels

Activates PKA, phosphorylates CFTR leading to Cl efflux and H2O, Na, K and HCO3 secretion