Acute Inflam. Dermatoses Flashcards Preview

Skin/Musculo Week 3 > Acute Inflam. Dermatoses > Flashcards

Flashcards in Acute Inflam. Dermatoses Deck (25)
Loading flashcards...
1
Q

Level of Skin Affected by Urticaria

A

Dermis

2
Q

Level of Skin Affected by Erythema Multiform

A

Epidermis & Dermis

3
Q

Level of Skin Affected by Steven Johnson Syndrome/Toxic Epidermal Necrolysis

A

Epidermis & Dermis

4
Q

Level of Skin Affected by Panniculitis

A

Subcutaneous

5
Q

Acute Inflammatory Dermatoses & the level of skin they affect

A

Urticaria ————– dermis
Erythema Multiform – Epi/dermis
Steven Johnson Syndrome — Epi/dermis
Toxic Epithelial Necrolysis —- Epi/dermis
Panniculitis ——————– subcutaneous

6
Q

Hallmarks of Urticaria

A
  • Transient wheals (lasting ~24 hours)
  • Pruritic
  • IgE & Histamine related
7
Q

Angiodema Hallmarks

A
  • Deep dermal & subcutaneous swelling
  • burning & painful
  • common around the lips and eyes
  • laryngeal involvement = EMERGENCY
8
Q

Clues & Methods of Diagnosing Urticaria & Angiodema

A
  • THOROUGH HISTORY
    • new meds?
    • exposure?
    • foods?
9
Q

Acute vs. Chronic Urticaria & Angiodema

A
Acute
	- usually allergic (IgE) response
	- most resolve within days
Chronic
	- idiopathic (cause unknown)
	- lasts >6 weeks
10
Q

Causes of Urticaria & Angiodema

A
  • Immune
    • IgE
    • Autoimmune
    • infection
  • Non-immune
    • physical contact
    • direct mast-cell degranulation
    • food w/ high histamine
11
Q

Urticaria/Angiodema Immune Rxn. Causes

A
  • Foods — shellfish, peanuts, fish, eggs, nuts, soy, etc
  • Latex
  • Stings (bees, wasps, ants, etc)
  • Medications (penicillin, sulfa, etc)
  • Aeroallergens (pollen, molds, etc)
12
Q

Autoimmune rxn. causing Urticaria/Angiodema

A
  • Hashimoto Immune Thyroiditis
    • anti-thyroid AB’s
  • System Lupus Erythamtous
13
Q

Infection Rxn. causing Urticaria/angiodema

A
  • VIRAL
  • fungal
    bacterial
    parasitic
14
Q

Physical causes of Urticaria/Angiodema

A
  • Sun
  • Cold
  • Cholinergic (sweat & heat)
  • friction
  • etc
15
Q

Foods w/ high levels of histamine

A
  • strawberries
  • tomatoes
  • shrimp
  • cheese
16
Q

Urticaria Lab evals

A
  1. dont get carried away –>
  2. CBC & basic chem panel
  3. throat culture?
  4. punch biopsy to exclude vasculitis if lesion is lasting >48 hrs
17
Q

Hallmarks of Erythema Multiform

A
  • Rxn. Pattern of blood vessels
    • circular red rash with raised center (iris shaped papules)
    • Target Lesion
  • involves extremities (especially palms & soles) & mucous membranes
  • NOT ITCHY
  • 50% are under 20 yrs. old (mostly male)
18
Q

Types of Erythema Multiform

A
  • Acute —- shows classic target lesion
  • EM minor — involves 1 or less mucosal sites
  • EM major — involves severe extensive skin & mucous membrane (steven johnson syndrome)
    • usually due to drug reaction
19
Q

Treatment of Erythema Multiform

A
  • 50% are idiopathic
  • Glucocorticoids for severe systemic
  • prevention
20
Q

What is Erythema Multiform Major also known as?

A

Steven Johnson Syndrome

21
Q

Steven Johnson Syndrome & Toxic Epidermal Necrolysis

A
  • Major problem = SLOUGHING OFF OF SKIN
  • usually drug induced or idiopathic
  • starts w/ skin tenderness & erythema
  • mucosal & epidermal necrosis
22
Q

SJS vs. TEN

A

SJS (steven johnson syndrome)

- 30%

23
Q

SJS/TEN treatment

A
  • remove drug

- HYDRATE

24
Q

Hallmarks of Panniculitis Erythema Nodosum

A
  • typically ANTERIOR SHINS
  • painful, tender nodules felt upon palpation
  • resolves naturally w/ rest & pain control
25
Q

Hallmarks of Panniculitis Erythema Induratum

A
  • Effects POSTERIOR legs

- associated with TB