Acute Leukemia

Question 1

lymphoblasts

Answer 1

TdT+, only present in precursor B-/T-cells

large, immature cells, w/ punched out nucleoli

Question 2

myeloblasts

Answer 2

MPO +, myeloperoxidase –> auer rod

Question 3

ALL and AML

Answer 3

based on phenotype of blasts

Question 4

ALL

Answer 4

acute lymphoblastic leukemia
TdT+ - DNA polymerase in the nucleus
ax w/ Down syndrome
B-ALL and T-ALL

Question 5

B-ALL

Answer 5

CD10+, CD19+, CD20+, PAX5
t(12;21) –> RUNX1 - ETV6; good PX, kids
t(9;22) –> BCR-ABL1; bad PX, adults, Ph+ ALL

Question 6

T-ALL

Answer 6

CD1,2,5,7+
thymic mass in a teenager
acute lymphoblastic lymphoma
NOTCH1 mutations