AD Flashcards
(33 cards)
1st step in an atopic march
AD
world wide cummulative prevalence
20%
% atopic if parents are atopic
more than 1/4 of offspring of atopic morhers develop AD in first 3 mnths of life.
1 parent is atopic, more than half of children will dev allergic sx. both parents- 79%. n
filaggrin prcesed by caspase 14 during terminal keratinocyte differentiation into highly hydroscopic pyrrolidone carboxylic acid and urocanic acid. collectively known as
Natural moosturizing factor ( NMF)
Ichthyosis vulgaris is xaused by mutations in what gene?
FLG gene
FLG mutations is also assoc w what 2 diseases independent of AD.
Ker pilaris.
allergic rhinitis
what palm finding is strongly assoc w FLG mutation.
Hyperlinear palms.
71% ppv for marked palmar hyperlinearity.
what dec gene expression lead to impaired sweating in AD
Dec claudin 3 expression
IL elevated in AD
IL 17,22
prevention in high risk.
Early moisturization statting before 3 wks of life w thick emollient may prevent AD.
probiotic admin during and after pregnancy dec AD by 14%
How many percent hs food allergy?
35% of children mod to severe AD.
85% of chil w AD will hve elev igE to food or inhalant allergens making dx of food allergy challenging. high false positive rate.
skin prick test ppv and npv
neg pred value >95%
Positive 30-65%
How many percent of AD occur in 1st yr of life
50% or more.
usually not until 2 months.
infantile pattern of AD disappears when ?
End ir 2nd yr of life.
adult AD Aafter 18 yo is only composed of how many px of AD pxs?
6-14
cutaneous stigmata/ signs.
Dennie morgan fold- below edge of lower eyelids.
headlight sign- nose is spared in extensice facial involvement. axillary vault and inguinal folds are spared due ti high humidity.
Nasal salute - nasal crease
What is hertoghe sign?
thinning of lateral eyebrows. sometimes present.
How many percent of AD develop cataract?
10%
chronic eczemarous lesions are often colonized by?
S aureus.
Bleach formula for AD n saureau infection
60 milliliters of bleach per 20 gallon bathtub water.
pxs w AD hve inc susceptibility to viral super infection esp from
HSV, VZV, coxackieF vaccinia; molluscum.
Easy most frequently in young children is usually associated with HSV type one transmitted from a caretaker or sibling.
eczema herpeticum
EcZema herpeticum tx
Antiviral tx and anti staphylococcal antibiotic.
Vaccination of ____ Is contraindicated in AD.
Small pox.
