ad active recall Flashcards
(10 cards)
Which enzymes regulate the amyloidogenic pathway?
β-secretase and γ-secretase
What does β-secretase cleave APP into?
C99 and sAPPβ
What role does sAPPα play in Alzheimer’s disease?
Neuroprotective, promoting cell survival and synaptic plasticity.
How does the Aβ peptide transform as it accumulates?
It shifts from a soluble alpha-helical form to an insoluble beta-sheet structure, eventually forming oligomers, fibrils, and amyloid plaques.
What protein is responsible for neurofibrillary tangles in Alzheimer’s disease?
Tau
What is tau’s normal function in healthy neurons?
Tau stabilizes microtubules by interacting with tubulin, supporting axonal transport and structural stability.
How does tau become pathological in Alzheimer’s?
Tau becomes hyperphosphorylated, detaches from microtubules, and forms oligomers, fibrils, and ultimately neurofibrillary tangles.
What is the clinical significance of NFT accumulation?
NFT accumulation strongly correlates with disease severity and cognitive decline.
What are the two main
pathological features of Alzheimer’s disease?
Amyloid-beta plaques and neurofibrillary tangles.
