Adaptive Immunity

Question 1

MHC are coded by which genes?

Answer 1

HLA genes

Question 2

What is the function of MHC molecule?

Answer 2

Bind & present peptide Ag fragments (derived from pathogens) on the cell surface for recognition by the appropriate T cells

Bind T cell receptors (TCRs)

Question 3

What are loci of MHC I?

Answer 3

HLA-A

HLA-B

HLA-C

(MHC I loci have 1 letter)

Question 4

What are loci of MHC II?

Answer 4

HLA-DP

HLA-DQ

HLA-DR

(MHC II loci have 2 letters)

Question 5

TCR & CD4 bind which major histocompatibility complex?

Answer 5

MHC II

Question 6

MHC I bind to which receptors?

Answer 6

TCR & CD8

Question 7

TCR & CD8 are specific for which MHC class?

Answer 7

MHC I

Question 8

TCR & CD4 are specific for which MHC class?

Answer 8

MHC II

Question 9

Where are MHC I expressed?

Answer 9

All nucleated cells

APCs

Platelets

(not on RBCs)

Question 10

Where are MHC II expressed?

Answer 10

APCs

Question 11

Which MHC class presents endogenously synthesized antigens (eg viral/ cytosolic proteins) to CD8+ cytotoxic T cells?

Answer 11

MHC I

Question 12

MHC II present exogenously synthesized antigens (eg bacterial proteins) to which type of cells?

Answer 12

CD4+ helper T cells

Question 13

Which MHC class presents exogenously synthesized antigens to CD4+ cytotoxic T cells?

Answer 13

MHC II

Question 14

How is antigen loaded onto MHC I?

Answer 14

Antigen peptides loaded onto MHC I in RER (rough endoplasmic reticulum)

after delivery via TAP (transporter associated with Antigen processing)

Question 15

In which MHC class is the antigen loaded following the release of invariant chain in an acidified endosome?

Answer 15

MHC II

Question 16

How is antigen loaded onto MHC II?

Answer 16

Antigen loaded following release of invariant chain in an acidified endosome

Question 17

β-microglobulin is associated with which MHC class?

Answer 17

MHC I

Question 18

What is the associated protein of MHC II?

Answer 18

Invariant chain

Question 19

What is the associated protein of MHC I?

Answer 19

β-microglobulin

Question 20

Which HLA subtype associated with hemochromatosis?

Answer 20

A3

Question 21

HLA subtype A3 is associated with which disease?

Answer 21

Hemochromatosis

Question 22

Which HLA subtype associated with Addison disease, myasthenia gravis, Graves?

Answer 22

B8

Question 23

HLA subtype B8 is associated with which diseases?

Answer 23

Addison disease

myasthenia gravis

Graves

Question 24

Which HLA subtype associated with psoriatic arthritis, ankylosing spondylitis, IBD-associated arthritis, reactive arthritis?

Answer 24

B27

Question 25

HLA subtype B27 is associated with which diseases?

Answer 25

Psoriatic arthritis Ankylosing spondylitis IBD-associated arthritis Reactive arthritis (PAIR - seronegative arthropathies)

Question 26

Which HLA subtype associated with celiac disease?

Answer 26

DQ2/ DQ8

Question 27

Which disease is associated with HLA subtype DQ2/ DQ8?

Answer 27

Celiac disease

Question 28

HLA subtype DR43 is associated with which diseases?

Answer 28

DM type I SLE Graves Hashimotos Addison disease

Question 29

HLA subtype DR2 is associated with which diseases?

Answer 29

Multiple sclerosis Hay fever SLE Goodpasture syndrome

Question 30

HLA subtype DR4 is associated with which diseases?

Answer 30

Rheumatoid arthritis DM type I Addison disease

Question 31

Which HLA subtype associated with Addison disease?

Answer 31

B8 DR3/ DR4

Question 32

Which HLA subtype associated with SLE?

Answer 32

DR2/ DR3

Question 33

Which HLA subtype associated with Graves disease?

Answer 33

B8 DR3

Question 34

Which HLA subtype associated with DM type I?

Answer 34

DR3/ DR4

Question 35

HLA subtype DR5 is associated with which diseases?

Answer 35

Pernicious anemia → vitamin B12 deficiency Hashimoto thyroiditis

Question 36

Which HLA subtype associated with Hashimotos?

Answer 36

DR3 DR5

Question 37

Which HLA subtype associated with rheumatoid arthritis?

Answer 37

DR4

Question 38

What are the seronegative arthropathies?

Answer 38

PAIR Psoriatic arthritis Ankylosing spondylitis IBD-associated arthritis Reactive arthritis