Adaptive Immunity: Memory (Lec 7)

Question 1

Naïve Mature B cells vs. Memory B cells

Answer 1

• Memory B cells have high affinity, class-switched BCRs on cell surface
• Memory B cells interact more effectively with antigen presenting cells (APCs)
  and thus get activated more easily

Question 2

Antibody Secretion vs. Memory (B cells)

Answer 2

• Majority of activated B cells that survive the germinal center reaction become
  plasma cells (antibody secreting cells)
• Some of these B cells become memory B cells
• cytokines that are provided to B cells during T cell help in the germinal center direct their fate

Question 3

Activated CD4 and CD8 T cells both generate…

Answer 3

effector (TE) and memory T (TM) cells

Question 4

Difference between Memory and Effector T cells

Answer 4

have a different splice
variant of an important co-receptor to be activated faster

Question 5

Central Memory T cells (TCM)

Answer 5

• Activated T cells that circulate the body and scan
  our secondary lymphoid tissues for infection
• Stem-cell like
• can be activated by antigen and cytokines

Question 6

Effector Memory T cells (TEM)

Answer 6

• Activated T cells that cannot enter our secondary lymphoid organs, only non-lymphoid tissues, to scan for infection
• already differentiated
• have high levels of effector molecules

Question 7

Tissue Resident Memory T cells (TRM)

Answer 7

Activated T cells that enter the tissues during repair of tissue damage can remain there

Question 8

As memory T cells get more differentiated during repeated antigen exposure…

Answer 8

they lose memory potential and eventually die