Addiction- Methods of modifying Flashcards
(52 cards)
What are the two methods of modifying criminal behaviour?
1- Agonist and Antagonist substitution
2- Aversion Therapy
What do Antagonist and agonist drugs do?
Common treatment is medication
- drugs work at the level of this synapse to alter behaviour
- act on specific biological processes
- either mimic or block the effects of particular substances on the brain
What is the Agonist drug called?
Methadone
What does methadone do?
Maintenance treatment, occupies dopamine receptors
-mimics effects of heroine without high
- activates receptors, reduces symptoms of withdrawal
- not uncontrolled or impulsive
- detoxification then abstinence
What is the recommended dosage for methadone (agonist drug)?
NICE- 10-40mg increased until there is no sign of withdrawal/intoxication
- maintenance dose 60-120mg a day
- see pharmacist each day for 3 months until they can continue without supervision
- alongside other psychosocial support
Why do addict have to o to the pharmacist every day to collect their dosage?
Methadone is still addictive
- may take more than one or sell it
Why is methadone given orally rather than an injection?
The blood concentration of methadone will rise and fall slowly, compared to the rush and crash of heroine which is injected
- digested differently
What is the Agonist substitution drug?
Naltrexone
What does naltrexone do?
Commonly used in the treatment of opioid addiction
- while methadone is used to manage the symptoms of withdrawal, naltrexone is used for addicts on recovery to prevent relapse
What is the biological action of the antagonist drug naltrexone?
- What is happening at the synapse?
It blocks europhic and pleasurable effect associated with opioids by blocking receptor sites, makes them less rewarding
What effect de naltrexone have on feelings produced by the drug?
Do no feel anything as it is made less rewarding
Who is given naltrexone as a treatment?
NICE- people who have stopped using opioids and have demonstrated they are highly motivated to stay free from drugs
How is naltrexone given?
Oral medication- available as an implant or depot injection (released lowly over a couple of weeks)
How can naltrexone be used for an alcohol addiction?
- offered alongside a psychological intervention
- after withdrawal has occurred, kept under supervision
- ensure they haven’t started drinking again
How can naltrexone be used for gambling?
more research needed but could be sued
Evaluation effectiveness: Substitution drugs
Research for Methadone
31 reviews on effectiveness of methadone
- 27 randomised controlled trials
(2+ conditions, single blind, Ps unaware of condition)
- higher levels pf retention for people using methadone compared to placebo/no treatment, lower rates of illicit drug use
- scientific methodology
- credible evidence
- more effective than placebo and no treatment
Evaluation effectiveness: Substitution drugs
What did Van de brink and Hassan’s meta-analysis find?
Large scale- effectiveness of a range of treatments concluding that as long as dosage is adequate then methadone is effective as a maintenance treatment
Evaluation effectiveness: Substitution drugs
X Comparing methadone to buprenorphine
B- milder medication, both agonist and antagonist properties
Ag- partially activated the D receptors, reducing withdrawal symptoms
Ant- blocks the receptors, preventing euphoria associated with opioids
B- much reduced chance of overdose
- ceiling effect, taking larger quantities will not produce a greater effect
Evaluation effectiveness: Substitution drugs
X Comparing methadone to buprenorphine
Marteau
Analysed data over a 5 year period and concluded that it was 6 times safer than methadone
Evaluation effectiveness: Substitution drugs
X Comparing methadone to buprenorphine
Whelan and Remski
Methadone is preferred, more effective in retaining patients
- person with addiction may prefer the feeling they get from methadone, more likely to continue with the treatment
- lower abstinence rate
Evaluation effectiveness: Substitution drugs
X Naltrexone, NICE
Nice reviewed17 studies concerning effectiveness of naltrexone for heroine addiction
x found conflicting results
x many of randomised control trials showed no significant difference between N and control treatment for retention
-N associated with reduction in relapse rates, highly motivated Ps, where they are closely monitored and offered support
Evaluation effectiveness: Substitution drugs
- Naltrexone, Lahti
Tested effectiveness of N on a small sample of gamblers, instructed to take N before gambling or when they felt the urge to
- significant decrease in gambling levels
X further research needed with placebo for comparison
Evaluation effectiveness: Substitution drugs
X Naltrexone, Gowing
NOT appropriate for all drug users
x completely stopped taking heroine as withdrawal symptoms may occur
x right attitude towards recovery, highly motivated to quit
x not as useful on those less motivated
Evaluation effectiveness: Substitution drugs
X Attrition rates
Drop outs are not reflected in the final results
x only show it works for those who are still in the study
x highly motivated to quit
x those not will have dropped out, may not have worked for them