Adenocarcinoma and Precursor Lesions of the Prostate Flashcards Preview

Unit 5: Path - The Lower Urinary Tract and Male Reproductive System > Adenocarcinoma and Precursor Lesions of the Prostate > Flashcards

Flashcards in Adenocarcinoma and Precursor Lesions of the Prostate Deck (9)
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1
Q

What is considered the precursor lesion to BPH?

A

Prostaticc Intraepithelial Neoplasia

2
Q

Describe Prostatic Intraepithelial Neoplasia

A

Prostatic ducts lined by cytologically atypical luminal cells and the concomitant decrease in basal cells

3
Q

High grade prostatic intraepithelial neoplasia is shown. What are typical findings?

A

Atypical cells with enlarged nuclei and prominent nucleoli

4
Q

What are typical markers for PIN?

A

aneuploidy, transforming growth factor -Alpha, type IV collagenase, bcl2

5
Q

What are typical histo characteristics of prostatic adenocarcinoma?

A
  • Increasing variability of gland size/configuration
  • Papillary/cribiform patterns
  • Little to no gland formation
6
Q

What is the most typical nuclear finding in prostatic adenocarcinoma?

A

One or two conspicuous nucleoli in a background of chromatin clumped near the nuclear membrane

7
Q

What is used to grade prostatic adenocarcinoma?

A

Gleason grading system

8
Q

Where does prostate adenocarcinoma metastasize earliest?

A

Obturator lymph node

9
Q

What are markers for prostate carcinoma?

A

PSA, alpha-methylacyl-CoA racemase