ADH Flashcards
(T/F) ADH is produced in the pituitary gland.
False - hypothalamus
Which two nuclei produce ADH in the hypothalamus?
paraventricular + supraoptic
ADH travels to the (anterior/posterior) pituitary and is stored where?
posterior
pars nervosa
What are the 3 primary factors that influence ADH secretion?
- osmolality
- volume
- pressure
What does osmolality refer to?
total solutes in a volumes (electrolytes in blood)
Match whether ADH secretion will increase or decrease with the following:
- Osmolality
- Volume
- Pressure
- increase
- decrease
- decrease
What sense changes in plasma osmolality?
osmoreceptors
What two regions of the brain contain osmoreceptors which can affect ADH secretion?
OVLT
SFO
What structure increases in permeability when ADH is secreted?
distal tubule + collecting duct of kidney
What two receptors regulate ADH secretion by sensing pressure and volume?
arterial baroreceptors
cardiopulmonary receptors
What two locations can arterial baroreceptors which regulate ADH secretion by found?
carotid sinus
aortic arch
Where are cardiopulmonary receptors that regulate ADH found?
cardiac atria & ventricles
What is an intermediate for how blood pressure and volume mediate secretion of ADH?
angiotensin II
How does ADH increase water permeability in the distal tubule/collecting duct of the kidney and therefore water reabsorption?
inserts aquaporins on apical membrane
When water reabsorption increases via ADH, what happens to urine volume and osmolality?
volume: decreases
osmolality: increases
