ADHD Flashcards

(44 cards)

1
Q

How common is ADHD?

A

1-5% prevalence

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2
Q

What are the core features of ADHD?

A

Inattention
Excessive activity
Impulsivity

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3
Q

Before which age must the symptoms of ADHD be present?

A

Before seven years old

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4
Q

What does it mean that the symptoms of ADHD are pervasive?

A

They must be present in more than one environment

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5
Q

ADHD is more common in females. T/F?

A

False

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6
Q

How do the symptoms of impulsivity present in a child with ADHD?

A
Poor awareness of danger
Social disinhibition
Excessively talkative
Poor peer relationships
Emotional dysregulation
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7
Q

Describe how attention develops over the first five years of life.

A
0-12 months fleeting attention
1-2 years rigid attention
2-3 years single Chanelled attention
3-4 years single focused attention
4-5 years dual challenged attention
More than 5years integrated attention
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8
Q

What genetic syndromes are associated with ADHD?

A

Fragile x syndrome
Klinefelters syndrome
Williams syndrome

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9
Q

Children affected with ADHD are often exposed to years of negative feedback. T/F?

A

True

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10
Q

How is brain structure affected by ADHD?

A

Smaller brain volume mainly affected frontal and parietal cortex
Smaller basal ganglia
Right dorsolateral prefrontal lobe reduced
Smaller cerebellum vermis

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11
Q

What are the comorbid disorders associated with ADHD?

A
Sleep disorders
Behavioural difficulties
Specific learning disabilities
Social communication difficulties
Anxiety symptoms
Tic disorders
Mood difficulties
Increase psychosocial factors
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12
Q

There is no specific diagnostic test for ADHD. What is involved in assessment?

A
Direct observations
Psycho educational assessment
Structured questionnaires
Identifying comorbid health problems
Developmental history
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13
Q

What factors need to be asked about in previous history with suspected ADHD?

A
Pregnancy
Patterns of feeding, sleeping and play
Activity levels
Impulsivity
Emotional reactivity
Ability to sustain interest
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14
Q

Once a thorough history of ADHD is established what additional checks are required?

A

Hearing and vision screening tests
Examination of neurological signs and physical anomalies
Baseline height and weight
Baseline blood pressure, pulse and heart sounds

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15
Q

What measures can be put in place to manage the environment of children with ADHD?

A

Provide a calm environment without background noise
Avoid too many distracting stimuli
Initially avoid situations that require quiet, still behaviour for long periods
Maintain structure and supervision

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16
Q

What behavioural management strategies can be used for children for ADHD?

A

Waiting to get the child’s attention before giving instructions
Give clear, short direct instructions
Providing support when needed
Ask the child to repeat the instructions back to ensure they have heard and understood them
Improve concentration skills with activities the child already enjoys
Plan ahead for problem situations
Model good listening skills

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17
Q

Which two psychostimulants are used in the treatment of ADHD?

A

Methylphenidate and dexamphetamine

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18
Q

What second line anti ADHD drug acts on noradrenaline transporters?

19
Q

What is the mechanism of action of guanfacine?

A

Acts as an alpha 2a adrenergic receptor agonist

20
Q

What is the mechanism of action of methylphenidate?

A

Blocks dopamine and noradrenaline reuptake

21
Q

What is the mechanism of action of dexamphetamine?

A

Releases dopamine stored in presynaptic vacuoles

22
Q

What is the prodrug form of dexamphetamine which can be used inADHD?

23
Q

What is the disadvantage of use of prolonged release tablet formations in ADHD?

A

Tablet cannot be crushed, chewed or broken before swallowing

24
Q

What factors are associated with persistence of ADHD to adulthood?

A
Progressive reduction in cerebellum and hippocampal volumes
Maternal depression
Marital discord
Negative parent child interaction
Family socioeconomic disadvantage
Familial ADHD
25
Describe the pathophysiology of ADHD?
There is a defective inhibitory response due to a compromised prefrontal cortex which leads to insufficient information processing Neutrons in the prefrontal cortex are unable to distinguish between important signals and background noise
26
Other than guanfacine, which unlicensed third line drug for ADHD can be used?
Clonidine
27
Which psychostimulant used in the treatment of ADHD can be dissolved in water to ease administration?
Dexamphetamine
28
What are the side effects of dexamphetamine?
``` Potential for growth retention Anorexia Blood pressure Heart rate irregularities Insomnia Irritability Abdominal pain Headaches ```
29
What factors must be monitored for patients administered atomoxetine for ADHD?
``` Pulse Blood pressure Heigh Wright LFTs Mood ```
30
What is the onset of atomoxetine?
6week
31
What are the side effects of atomoxetine?
``` Nausea and vomiting Excessive tiredness Insomnia Abdominal pain Appetite suppression Weight loss Constipation Headaches Mood swings Hepatic impairment Increased heart rate and blood pressure Sundial ideation ```
32
What are the side effects of clonidine and guanfacine?
Sedation Dizziness Hypotension
33
Why is it relevant that guanfacine is a CYP 3A4 substrate?
Guanfacine is is metabolised by cytochrome p450 system so its metabolism is affected by other drugs which affect metabolism
34
It may be possible to use antidepressants in the treatment of ADHD.T/F?
True
35
What are the side effects of mofafinil?
Appetite Abdominal pain Dry mouth Tachycardia
36
What type of drug is modafinil?
It is a weak psychostimulant
37
What is epidemiology of ADHD?
``` 1-2% prevalence associated with poverty, lower social class and lower family income ```
38
There is a genetic component to ADHD. T/F?
True
39
What environmental factors have been implemented in the development in ADHD?
``` Low birth weight maternal smoking and alcohol use in pregnancy lead exposure poverty iron deficiency antenatal antidepressant use ```
40
What are the hyperactive-impulsive symptoms of ADHD?
fidgeting or squirming in seat leaves seat in classroom / other situations where expected to be seated often runs about or climbs excessively in inappropriate situations difficulty playing quietly often on the go often talks excessively blurts out answers before question completed difficulty waiting their turn often interrupts or intrudes on others
41
What are the inattentive symptoms of ADHD?
fails to give close attention to details / makes careless mistakes difficulty sustaining attention in tasks does not seem to listen when spoken to directly does not follow through on instructions and fails to complete schoolwork/chores difficulty organising tasks and activities avoids, dislikes or is reluctant to engage in tasks that require sustained mental effort easily distracted by extrenaous stimuli forgetful in daily activities
42
What is involved in the mental status examination in ADHD?
Appearance, alertness and orientation ability to relate with interviewer speech, mood, affect on thought process, estimation of cognitive ability over signs of ADHD - motor restless, inattention, working memory impairment
43
What is involved in psychoeducation in ADHD?
Educated about symptoms, typical source, potential treatments referral to support and advocacy organisations outline resources and toolkits important for parents, children, and teachers
44
Doses of psychostimulants in ADHD should be titrated upwards until optimal dose found. T/F?
True