Adrenal

Question 1

Action of cortisol
Cho ptn fat

Answer 1

• Hyperglycemia
  Catabolic
  Lipolytic → redistribution of fat

Question 2

4 anti in cortisol

Answer 2

’ Anti-vitamin D
Anti-inflammatory
Anti-allergic → ↓ lymphocytes ↓ eosinophils, basophils
Anti-stress

Question 3

Action of cortisol on blood

Answer 3

↑ RBCs
↑ neutrophils

Question 4

Action of cortisol on blood

Answer 4

↑ RBCs
↑ neutrophils

Question 5

Feature suggest ectopic ACTH

Answer 5

O short duration ② weigh loss ③ severe ↓ K ④ severe DM

Question 6

Investigation of Cushing

Answer 6

• 24-hr free urinary cortisol
• low- dose dexamethasone suppression test

Question 7

Gold standard for distinguishing between () Cushing D. And ectopic Cushing

Answer 7

IPSS

Question 8

In IPSS if ratio 1:1

Answer 8

Ectopic Cushing

Question 9

Medical TTT in Cushing

Answer 9

① metyrapone →ß-hydroxyls blocker

② ketoconazole → hepatotoxicity
③ ↓ ACTH

Question 10

Sarcoidosis and hemochromatosis’s cause

Answer 10

1 ry Addison

Question 11

The most common cause of I primary Addison in developed

Answer 11

Autoimmune

Question 12

C/p of Addison

Answer 12

↓↓↓
Hypoglycemia
Hypotension
Asthenia

↑↑↑
Hyper pigmentation in 1ry
Hyper acidosis
Hyper k+

Question 13

TTT of Addison

Answer 13

• Steroid replacement
  Hydrocortisone or predmisolone
• aldosterone replacement
  Fluoro cortisone acetate
  *
  Vitamin D

Question 14

Sudden withdrawl of chronic cortisone therapy cause

Answer 14

Adrenal crisis

Question 15

Waterhouse-freid Chon cause

Answer 15

Adrenal crisis

Question 16

TTT of adrenal crisis

Answer 16

IV fluid
Cortisone

Question 17

Regulation of: aldosterone

Answer 17

Angiotensin Il
Extra K level

Question 18

Secondly hyperaldestorism with HTN

Answer 18

Renal A. Stenosis

Question 19

Cause of 2 ry ↑ aldosterone

Answer 19

Renin-producing tumor
Renal A stenosis
It vent HF
Nephrotic
Cor pulmonale

Question 20

C/p of conn’s

Answer 20

① hypertension manifest
② hypokalemica
Ms weakness - fatigue - polyuria
③ alkalosis
Tetany Ca

Question 21

Plasma renin activity in Conn

Answer 21

Suppressed

Question 22

T TT in Conn [ adrenal hyperplasias]

Answer 22

Aldosterone antagonist
(1) spironolactone

Question 23

Pheochromocytoma associated with

Answer 23

30%
① VHL syndrome
② men 2
③ NF 1
④ HOCM

Question 24

C/p of pheocromocytoma

Answer 24

• Headache
  *Palpitation
• sweating
• postural hypotension
• hypertension
• tachyarrythemia
• café au Lait spots

Question 25

End-product of catecholamine

Answer 25

Vanillymandelic acid

Question 26

Adverse effects of oral corticosteroid therapy Include

Answer 26

a. Peptic ulceration
b. Hypertension
c. Avascular bone necrosis

Question 27

Postural hypotension and systole BP ↓ 20 and diastole BP ↓ 10
Common in

Answer 27

Adrenal insufficiency

Question 28

Short synacthen test diagnostic to

Answer 28

Adrenal failure

Question 29

20. All of the following are featured by dermal hyperpigmentation

Answer 29

B. Bronchogenic carcinoma C. Addison’s disease
D. Hemochromatosis
E. Nelson’s syndrome

Question 30

Weight In pheocromocytoma

Answer 30

Loss

Question 31

Vanillylmandelic acid (VMA) excretion is increased in urine in:

Answer 31

Pheochromocytoma

Question 32

DDX of pheochromocstome

Answer 32

B. Primary aldosteronism C. Hypoglycemia
D. Cushing’s disease
E. Fibromuscular dysplasia

Question 33

initial test to confirm the diagnosis of Cushing’s syndrome?

Answer 33

Low dose dexamethazone suppression te

Question 34

What are the major effect of excess cortisol?

Answer 34

Catabolic+ immunosuppression

Question 35

Adrenal Hge and insufficiency due to N. meningitides is called:

Answer 35

Waterhouse-Frederichsen syndrome