Flashcards in Adrenergic Agonist. Deck (20):
Dopamine perfusion relevance
Drug of choice for cardiogenic or septic shock. Renal failure. Hypertension. Congestive heart failure
Low dose (1-2 mcg/kg/min.)=vasodilation to kidneys brain and viscera
Medium dose (2-10 mcg/kg/min.)= increases CO
High dose (>10 mcg/kg/min)= increased alpha receptors activity which results in arterial and Vino constriction.
Dobutrex. Synthetic direct acting beta-1 agonist. Increases cardiac rate and output with few vascular effects.
Corlopam. Agonist of Peru Friel dopamine receptors. Used as a rapid basal dilator to treat severe hypertension. It is a rest Seemic mixture and the right-handed isomer is active.
Direct acting synthetic adrenergic agonist stimulates both alpha-1 and alpha-2 receptors. Produces vasoconstriction and decrease his congestion.
New synephrine, sudafed pe. Direct acting synthetic adrenergic drug that binds to alpha-1 receptors. Vasoconstrictor that raises both the systolic and diastolic blood pressure's. Induces reflex bradycardia and is used to treat hypotension.
Catapres duraclon. Alpha-2 agonist that is used for hypertension
Albuterol and terbutaline
Accuneb,pro air ha, ventolin. Terbutaline has no trade name. Short acting Beta two agonist used for bronchodilators. Albuterol use for acute asthma. Terbutaline used for uterine relaxant.
Salmeterol and formoterol
Serevent diskus, foradil aerolizer/performoist. Long-lasting beta-2 agonist. Last up to 12 hours compared to albuterol which only last three
Mybetriq. Beta three agonist that relaxes the detrusor muscle and increase his bladder capacity
Adderall. Indirect acting adrenergic agonist. Increases blood pressure through alpha-1 and beta-1 stimulation.
Local anesthetic that blocks sodium chloride norepinephrine transporter required for cellular uptake of norepinephrine in the neuron.
Ephedrine and pseudo ephedrine
Ephedrine has various. Sudafed. Mixed action adrenergic agents. Not only really stored nori from nerve endings but also directly stimulate both alpha and beta receptors. Excellent absorption and penetrate into CNS. Long duration of action because they are not degraded by COMT and MAO.
Tradename adrenaline/EpiPen. Direct acting agonist. causes beta-1 stimulation on both the heart and the kidneys therefore causes increased contractility and renin release. Constricts arterials in the skin mucous membranes which are alpha effects. Dilates vessels to the liver and skeletal muscle which are beta-2 effects. Overall effect is it increased systolic blood pressure with a slight decrease and diastolic pressure due to beta-2 receptor
Tradename levophed. In therapeutic doses mostly affects alpha receptors. Causes vasoconstriction and increases both systolic and diastolic blood pressure's. Stimulates barrow receptors which induces cabal activity and causes reflex bradycardia. Does not affect inotropy. Atropine is still given before norepinephrine to block vagal affects.
Isuprel. Direct acting agonist. Stimulates both beta 1 and beta 2 receptors. Stimulation of heart contraction, rate, output. Decreased peripheral resistance and bronchodilator.
No trade name. Metabolic precursor norepinephrine direct acting agonist. At high doses causes vasoconstriction by activating alpha-receptors where as low doses it stimulates beta-1 receptors. It increases renal bloodflow via D receptors.
six steps of norepinephrine synthesis
1.)synthesis of nore via tyrosine to dopa hydroxylation (rate limiting step) dopa decarboxylated into dopamine
2.)uptake into vesicles where it is converted to NORE
3.)release of NT. influx of ca causes Nt release
4.)binding to receptor either pre which causes feedback loop and stops production of nore or post
5)either diffuses away or inactivated by COMT or absorbed by presynaptic (most common)
6.)may be reused or degraded by MAO
increase in vascular tone increase in BP Mydriasis -Increased bladder tone -Increased tension in prostate