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2nd U2 Pharm > Adrenergic Receptor Agonists/Antagonists > Flashcards

Adrenergic Receptor Agonists/Antagonists Flashcards

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1
Q

What are the 2 non-selective adrenergic receptor agonists?

A

Norepinephrine

Epinephrine

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2
Q

What is norepinephrine an agonist for?

A

a1
a2
B1

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3
Q

What is epinephrine an agonist for?

A

a1
a2
B1
B2

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4
Q

Name the indirect acting adrenergic receptor agonist…

A

Amphetamine

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5
Q

What is the mechanism of action for amphetamine?

A

Increases release of NE

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6
Q

What class does isoproterenol fall in?

A

Non-selective B agonist

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7
Q

What is isoproterenol an agonist for?

A

B1

B2

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8
Q

What class does dobutamine fall in?

A

B1-selective B agonist

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9
Q

What is dobutamine an agonist for?

A

B1

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10
Q

What class does albuterol fall in?

A

B2-selective B agonist

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11
Q

What is albuterol an agonist for?

A

B2

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12
Q

What class does terbutaline fall in?

A

B2-selctive B agonist

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13
Q

What is terbutaline an agonist for?

A

B2

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14
Q

Non-selective agonist used for acute hypotension

A

NE

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15
Q

Non-selective agonist used for anaphylactic shock; also combined with local anesthetics and used to treat glaucoma…

A

Epi

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16
Q

Indirect acting adrenergic receptor agonist used for the treatment of ADHD, narcolepsy, recreation

A

Amphetamine

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17
Q

What are the side effects of NE?

A

HTN
arrhythmia
headache

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18
Q

What are the side effects of EPI?

A

Palpitation
arrhythmias
headache

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19
Q

What are the side effects of amphetamine?

A

HTN
insomnia
anxiety
arrhythmias

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20
Q

Non-selective B agonist used for the treatment of shock, and heart block…

A

Isoproterenol

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21
Q

B1-selective B agonist used for the treatment of cardiac decompensation, shock, and heart block…

A

Dobutamine

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22
Q

B2-selective B agonist used to prevent or reverse exercise-induced bronchospasm; mild asthma; COPD…

A

Albuterol

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23
Q

B2-selective B agonist used to prevent or reverse exercise-induced bronchospasm; mild asthma; COPD and early labor…

A

Terbutaline

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24
Q

What are the side effects of isoproterenol?

A

Palpitation
Tachyarrhythmia
headache

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25
What are the side effects of dobutamine?
Tachyarrythmias | HTN
26
Albuterol and terbutaline can potentially mask what?
Progressively severe inflammation
27
What are the side effects of albuterol and terbutaline?
Tachycardia | Muscle tremor
28
a1-selective a agonist..
Phenylephrine
29
What is phenylephrine an agonist for?
a1
30
What are the 2 a2-selective a agonists?
Clonidine | a-methyldopa
31
What is the mechanism of action for clonidine?
CNA a2 agonist
32
What is the mechanism of action for a-methyldopa?
Metabolite (a-methylnorepinephrine) activates CNS a2 receptors
33
What is phenylephrine used for?
Nasal congestion | postural hypotension
34
What is clonidine used for?
HTN Shock Drug withdrawal
35
What is a-methyldopa used for?
HTN
36
What are the side effects of phenylephrine?
HTN | Reflex bradycardia
37
What are the side effects of clonidine and a-methyldopa?
Sedation
38
a2-selective a agonist that can cross the BBB and is a prodrug...
a-methyldopa
39
Selective dopamine agonist...
Fenoldopam
40
What is fenoldopam an agonist for?
D1 only
41
Mixed acting (direct/indirect) adrenergic receptor agonist...
Dopamine
42
What is dopamine and agonist for?
D1--low dose (direct) a1--high dose (direct with some indirect (NE)) B1--med dose (direct with some indirect (NE))
43
What is Fenoldopam used for?
Increase blood flow at renal, mesenteric and cerebral arteries
44
What is dopamine used for?
Shock Renal failure Hypotension
45
What is the side effect of dopamine?
Vasoconstriction at high doses
46
Name the 2 non-selective a-antagonists...
Phentolamine | Phenoxybenzamine
47
What is phentolamine an antagonist for?
a1 | a2
48
What is phenoxybenzamine an antagonist for?
a1 a2 non-competitive blocker--covalently bind receptor
49
What are the non-selective a-antagonist drugs, phentolamine and phenoxybenzamine, used for?
Pheochromocytoma Raynaud's Frostbite
50
What are the side effects of all the a-antagonists?
Postural hypotension
51
What are the side effects of the non-selective a-antagonists?
Postural hypotension | Inhibit ejaculation
52
Name the 2 a1-selective antagonist...
Prazosin | Terazosin
53
What are the uses of Prazosin and Terazosin?
Primary HTN | BPH
54
Name the 2 non-selective B antagonist (1st generation)
Propranolol | Timolol
55
What are propranolol and timolol antagonist for?
B1 | B2
56
What non-selective B antagonist is used to treat angina, HTN, and arrhythmias?
Propranolol
57
What are the side effects of propranolol and timolol?
Bradycardia Bronchoconstriction Sexual dysfunction
58
Non-selective B antagonist used to treat glaucoma...
Timolol
59
Name the 3 2nd generation B1-selective antagonists...
Metoprolol Atenolol Bisoprolol
60
What are all 3 2nd generation B1-selective antagonists used to treat? (Metoprolol, Atenolol, Bisoprolol)
HTN Angina Arrhythmias CHF
61
What are the side effects of all 3 2nd generation B1-selective antagonists? (Metoprolol, Atenolol, Bisoprolol)
Bradycardia | sexual dysfunction
62
What are the 2 3rd generation "A" non-selective B antagonists?
Carvedilol | Labetalol
63
What are all the 3rd generation B antagonists used for?
CHF | HTN
64
What are the side effects of the 2 3rd generation "A" non-selective B antagonists? (Carvedilol and Labetalol)
Bradycardia | Fatigue
65
Name the 3rd generation "B" B1 selective antagonist...
Betaxolol
66
What is betaxolol used for?
CHF | HTN
67
What are the side effects of Betaxolol?
Bradycardia
68
What is the indirect acting adrenergic receptor agonist, which works through increasing cytoplasmic NE release?
Tyramine
69
A drug that prevents NE re-uptake and is used as a local anesthetic and vasoconstrictor?
Cocaine
70
What are the side effects of cocaine?
Insomnia Anxiety Arrhythmias
71
Name the 3 nerve ending blockers...
Guanethidine Reserpine a-me-tyrosine
72
What is the mechanism for guanethidine?
False NT--causing vesicles to become full of guanethidine rather than NE
73
What is guanethidine used for?
antihypertensive
74
What isn't Guanethidine used?
Many and serious side effects | unable to cross BBB
75
Nerve ending blocker that causes release of empty vesicles by it binds the re-uptake transporter and stops NE from reentry...
Reserpine
76
What is reserpine used for?
it is an old antiHTN
77
What is the mechanism for a-me-tyrosine, a nerve ending blocker?
Inhibits tyrosine hydroxylase--decreasing NE synthesis
78
What is a-me-tyrosine used for?
treatment of pheochromocytoma
79
Mixed, direct B2/indirect agonist used for nasal decongestion and anorexia?
Ephedrine

2nd U2 Pharm (9 decks)

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