Adrenergic receptors Flashcards
(35 cards)
What kind of receptor is alpha 1?
A Gq coupled receptor
What kind of receptor is alpha 2?
A G-inhibitory receptor
What kind of receptor are beta receptors?
G-stimulatory
Where in blood vessels are adrenergic receptors located?
Tunica media
What happens to the blood flow to the kidneys with sympathetic innervation?
It reduces - reducing urine output
Which receptor decreases blood flow to the GIT, skin and Kidneys with sympathetic innervation?
Alpha-1 receptors
Which receptor increases blood flow to the muscles with sympathetic innervation?
Beta 2 receptors
Which adrenergic receptors are found on the cardiovascular system?
Alpha 1- constriction
Beta 2 - relaxation
What is the impact of sympathetic innervation on the eye?
Ciliaris muscle relaxes - this causes the lens to flatten due to beta 2 receptors. Pupil dilation due to contraction and therefore by alpha 1 receptors
What is the impact of sympathetic innervation on the salivary glands?
Beta 2 receptors - reduce water and electrolyte rich saliva and increase mucin
Alpha 1 decreases the blood flow to the salivary glands
Which receptors does carvedilol act on?
It is non-selective and therefore acts on both alpha and beta adrenergic receptors
Which receptors does methyldopa act on?
Alpha 2 receptors
Where are alpha 1 receptors located?
Blood vessels - peripheral vasoconstriction Eyes - mydriasis (dilation) Bladder sphincter - retention Liver - glycogenolysis Kidney - inhibit renin release
Which receptor causes urinary bladder sphincter constriction?
Alpha 1 receptor to sympathetic activation
Where are alpha 2 receptors located?
Pre-synaptic membranes - decrease noradrenaline release
Pancreas - reduced insulin secretion
Where are Beta 1 receptors located?
Heart - inc heart rate, inc AV node conduction, inc contractility
Juxtaglomerular cells - inc renin
Where are Beta 2 receptors located?
Bronchiole smooth muscle - dilation
Vascular and skeletal smooth muscle - vasodilation
GI tract - muscle relaxation inhibits mobility
Uterus - muscle relaxation inhibits contraction
Pancreas - increase insulins secretion
Where are Beta 3 receptors located?
Lipolysis in fat
Bladder - relaxation, retention of urine
What kind of drug is adrenaline?
Non selective adrenergic agonist
Catecholamine (needs to be injected)
What kind of drug is phenylephrine?
A selective alpha 1 agonist
Used for nasal congestion
What kind of drug is clonidine?
A selective alpha 2 agonist
Used for withdrawal but can also treat hypertension
What kind of drug is terbutaline?
A short acting beta 2 agonist (inhibits uterine contraction)
What kind of drug is salmeterol?
A long acting beta 2 agonist
What kind of drug is fometerol?
A long acting beta 2 agonist
