Adrenergics

Question 1

What is the preferential binding to beta-1?

Answer 1

Isoproterenol > epinephrine = norepinephrine

Question 2

What is the preferential binding to alpha-1?

Answer 2

Epinephrine >/= norepinephrine&raquo_space; isoproterenol

Question 3

What is the preferential binding to beta-2?

Answer 3

Isoproterenol > epinephrine&raquo_space; norepinephrine

Question 4

What is the preferential binding to alpha-2?

Answer 4

Epinephrine >/= norepinephrine&raquo_space; isoproterenol

Question 5

What is the effect of beta-1 activity on blood pressure?

Answer 5

Beta-1 increases HR and SV

BP=(HR)(SV)(TPR)

Question 6

What are the effect of alphas-1&2 activity on blood pressure?

Answer 6

Alpha-1 increases TPR
Alpha-2 decreases TPR

BP=(HR)(SV)(TPR)

Question 7

What is the effect of beta-2 activity on blood pressure?

Answer 7

Beta-2 decreases TPR

BP=(HR)(SV)(TPR)

Question 8

Besides the alphas and betas, what other receptor activity can effect BP?

Answer 8

Muscarinic receptors

Question 9

What transmitter binds to muscarinic receptors?

Answer 9

Acetylcholine

Question 10

What is the effect of muscarinic activity on blood pressure?

Answer 10

Decreases HR and TPR

BP=(HR)(SV)(TPR)

Question 11

What is the transmitter from the pre-ganglionic fibers? What kind of receptor is used in the sympathetic pathway?

Answer 11

ACh

Nicotinic receptor

Question 12

What is a fancy ganglion?

Answer 12

Adrenal Medulla

Question 13

What receptor(s) are activated by dopamine?

Answer 13

Beta-1 and alpha-1

Dope is #1! So Beta1 and alpha1

Question 14

Because dopamine activates beta-1 and alpha-1 receptors, what is its effect on BP?

Answer 14

Dopamine will increase BP

Beta-1 increases HR and SV
Alpha-1 increases TPR

Question 15

What would be necessary to inhibit dopamine activity?

Answer 15

Alpha-1 blocker (Terazosin)
Beta-1 blockers (MAA)

Non-selectives
Alpha (Trazadone)
Beta (non-MAA -alol’s)

Question 16

What is Dobutamine?

Answer 16

Dobutamine is a beta-1 agonist. butamIne is beta1. Buta, beta, its close. i is like 1. so Beta 1. “Will be on the test”

Question 17

What is the effect of Dobutamine on BP?

Answer 17

Dobutamine increases BP

Beta-1 increases HR and SV

Question 18

Is Dobutamine permanent?

Answer 18

No…Dobutamine reversibly binds to beta-1 receptors

Question 19

What would be needed to block Dobutamines effects?

Answer 19

Beta-1 blockers (MAA)

Non-specific beta-blockers

Question 20

What is an alpha-1 agonist?

Answer 20

Phenylephrine
(ends in ephrine, so it acts like epi and targets alpha-1, thats how Jeff remembered it in simpler times.Still kinda works)

Question 21

What effect does Phenylephrine have on BP?

Answer 21

Phenylephrine increases BP

Alpha-1 increases TPR

Question 22

What would be needed to block Phenylephrines effects?

Answer 22

Alpha-1 blocker (terazosin)

Non-specific alpha-blocker (trazadone)

Question 23

What are some examples of beta-2 agonists?

Answer 23

Metaproterenol
Terbutaline
Albuterol
Ritodrine (delays labor)
Salmeterol

Mnemonic alert: Beta 2 increases blood flow. What needs more blood flow? Erections.

Men Think About Raunchy Sex

Question 24

What effect do beta-2 agonists have on BP?

Answer 24

Beta-2 agonists decrease BP

Beta-2 decreases TPR

Question 25

What would inhibit the effects of beta-2 agonists?

Answer 25

Non MAA beta-blockers

Question 26

What effect do Clonidine, alpha-Methyldopa, and Guanabenz have on BP?

Answer 26

They decrease BP

Question 27

What causes Clonidine, alpah-Methyldopa and Guanabenz to DEcrease BP?

Answer 27

They are alpha-2 agonists... suppress sympathetics through actions in medulla oblangata

Question 28

What drug would block the effects of the alpha-2 agonists?

Answer 28

Trazadone

Question 29

What is the effect of cocaine and imipramine?

Answer 29

Potentiate sympathetics...block reuptake by nerves Increases blood pressure

Question 30

What is the effect of tyramine/amphetamine/ephedrine?

Answer 30

Release of norepinephrine by reversing axoplasmic uptake pump Increases blood pressure Remember how ephedrine was like amphetamine durin CPC last year? Just freaking remember tyramine, its one drug, don't worry about mnemonic.

Question 31

What is the effect of Reserpine?

Answer 31

Jeff edited this. Depletes norepinephrine...blocks vesicular uptake Decreases blood pressure His PowerPoint stated what I put on there. It did say vascular before, which his notes said. But that doesn't make sense where power point explanation is more clear.

Question 32

What is the effect of Guanethidine/guanadrel?

Answer 32

Depletes norepinephrine..releases norepinephrine from vesicles GUAN is GONE (in terms of norepinephrine is GONE) Decreases blood pressure

Question 33

What drug can stop effect of Tyramine?

Answer 33

Cocaine. Blocks the axoplasmic pump that Tyramine, amphetamine and ephedrine would use.

Question 34

What can't you eat if on pargyline?

Answer 34

Tyramine. It is an MOA inhibitor so you have moe catechu lameness. Remember that Tyramine acts like amphetamine and causes release into blood stream

Question 35

What is pargyline?

Answer 35

Irreversible MAO

Question 36

What is the beta 2 agonist that starts with M?

Answer 36

Metaproterenol (Men)

Question 37

What is the beta 2 agonist that starts with T?

Answer 37

Terbutaline (Think)

Question 38

What is the beta 2 agonist that starts with A?

Answer 38

Albuterol (About)

Question 39

What is the beta 2 agonist that starts with R?

Answer 39

Ritodrine (used to delay labor) [Raunchy]

Question 40

What is the beta 2 agonist that starts with S?

Answer 40

Salmetrol (Sex)