adrenergics

Question 1

EPI - MOA

Answer 1

bronchodilator (b2)

Question 2

EPI - use

Answer 2

anaphylaxis
shock: vasodilate
local anesthetic: vasoconstrict (a1)

Question 3

EPI - SE

Answer 3

high BP
high HR
hyperthyroidism: upregulate b1

Question 4

NE - MOA

Answer 4

vasoconstriction (a1)

Question 5

NE - use

Answer 5

shock
hypotension
decrease renal bloodflow

Question 6

NE - SE

Answer 6

hyperthyroidism: upregulate b1

Question 7

DA - dosing/MOA

Answer 7

low: d1 - increase renal bloodflow
med: d1 & b1 - increase BP, CO
high: d1, b1, a1/a2 - vasoconstriction

Question 8

DA - use

Answer 8

shock

congestive heart failure

Question 9

DA - SE

Answer 9

arrhythmias

nausea, vomiting (d1)

Question 10

indirect sympathomimetics - MOA

Answer 10

induce NT release

block NT reuptake

Question 11

amphetamine - use

Answer 11

ADHD, narcolepsy

Question 12

cocaine - MOA

Answer 12

block Na+ channels (prevents AP)

Question 13

cocaine - use

Answer 13

topical anesthesia

Question 14

tyramine - SE

Answer 14

contraindicated if taking MAO inhibitor - isn’t broken down, replaces NE in nerve terminals, causes fatal HTN

Question 15

mixed sympathomimetics: ephedrine

Answer 15

weak a1, b agonist
release NE
decongestant

Question 16

direct a1 agonist

Answer 16

vasoconstriction

constrict sphincter

Question 17

Milodrine

Answer 17

a1 agonist

prodrug

use: orthostatic hypotension, incontinence

Question 18

Metaraminol

Answer 18

a1 agonist

use:
shock
hypotension

Question 19

Phenylephrine

Answer 19

selective a1 agonist

use:
nasal decongestant
mydriasis
hypotension

Question 20

Oxymetazoline (eye drops)

Answer 20

a1 agonist
a2 partial agonist

use:
vasoconstriction of eye vessels

Question 21

direct a2 agonist: clonidine

Answer 21

inhibits sympathetic outflow

use:
HTN
drug withdrawal
ADHD

SE:
abrupt withdrawal causes tachychardia/arrhythmias

Question 22

alpha antagonist

Answer 22

vasodilation

sphincter relaxation

Question 23

phentolamine

Answer 23

competitive alpha antagonist

MOA:
vasodilation
block inhibitory a2 receptors

use:
short-term control of HTN

SE:
hypotension
tachycardia
nasal congestion

Question 24

phenoxybenzamine

Answer 24

irreversible alpha antagonist

use:
pleochromocytoma (adrenal tumor secretes too much NE)

SE:
hypotension
tachycardia
nasal congestion

Question 25

prazosin

Answer 25

selective a1 antagonist use: HTN SE: hypotension

Question 26

direct beta agonist

Answer 26

cardiac stimulant

Question 27

isoproterenol

Answer 27

b1 agonist - increase HR | b2 agonist - vasodilate

Question 28

dobutamine

Answer 28

b1/b2 agonist - increase HR, vasodilate | a1 agonist - vasoconstrict

Question 29

direct b2 agonist

Answer 29

b2 - think lung inhibit release of inflammatory mediators use: asthma SE: CV stimulation tremors

Question 30

albuterol

Answer 30

direct b2 agonist use: asthma, delay labor

Question 31

terbutaline

Answer 31

direct b2 agonist oral, IV

Question 32

salmeterol

Answer 32

direct b2 agonist inhaled, long-acting

Question 33

direct b3 agonist: mirabegron

Answer 33

MOA: relax detrussor M use: overactive bladder

Question 34

beta antagonists

Answer 34

"lol" decrease HR, contractility, CO, O2 demand risk: asthma, COPD, diabetes discontinue slowly

Question 35

propanolol

Answer 35

b1, b2 antagonist membrane stabilizing use: arrhythmias, MI, HTN, angina, hyperthyroidism, anxiety SE: bradycardia, depression, insomnia

Question 36

nadolol

Answer 36

b1, b2 antagonist non-membrane stabilizing long acting

Question 37

carvedilol

Answer 37

b1, b2 antagonist a1 antagonist - decrease BP use: CHF

Question 38

labetalol

Answer 38

b1, b2 antagonist a1 antagonist - decrease BP intrinsic sympathomimetic activity use: CHF

Question 39

timolol

Answer 39

b1, b2 antagonist use: topical, glaucoma

Question 40

carteolol

Answer 40

b1, b2 antagonist use: topical, glaucoma

Question 41

b1 antagonist

Answer 41

decrease HR, contractility, CO

Question 42

atenolol

Answer 42

b1 antagonist use: HTN angina MI risk: asthma, diabetes doesn't cross BBB

Question 43

metoprolol

Answer 43

b1 antagonist use: HTN angina MI crosses BBB