Adrenergics Flashcards Preview

Neuro 2 Exam 1 > Adrenergics > Flashcards

Flashcards in Adrenergics Deck (26):
1

alpha agonists: 2

Phenylephrine (Neo-synephrine), Clonidine (Catapres)

2

Mixed alpha and Beta agonists: 2

Norepinephrine (Levophed), Epinephrine (Adrenalin)

3

Beta agonists: 4

Dobutamine (Dobutrex), Isoproterenol (Isuprel), Terbutaline (Brethine), Albuterol (Ventolin)

4

Dopamine agonists: 2

Dopamine (Intropin), Fenoldopam (Corlopam)

5

Direct acting adrenomimetics: 4

Alpha agonists, mixed alpha/beta agonists, beta agonists, dopamine agonists

6

Indirect adrenomimetics: 4

Inhibitors of re-uptake of DA/NE, inhibitors of MAO, reverse NE/DA uptake mechanisms that increase their release, Releasing agent AND a direct adrenergic receptor agonist

7

Drug that inhibits re-uptake of DA and NE

-family

cocaine, indirect adrenomimetic

8

Two inhibitors of MAO

-what family

Selegiline (Eldepryl), and Phenelzine (Nardil)

they are indirect adrenomimetics

9

Three drugs that reverse NE and DA uptake mechanisms and increase their release

-what family

Amphetamines, Methylphenidate (Ritalin), Tyramine (not actually a drug but byproduct of tyrosine metabolism)

-they are indirect adrenomimetics

10

Drug that is a releasing agent AND a direct adrenergic receptor agonist

-what family

-Ephedrine

-indirect adrenomimetic

11

Direct acting antiadrenergic drugs

-3 broad classes

a-adrenoceptor antagonists, Mixed blockers, B-adrenoceptor blockers

12

-Two non selective (a1 and a2) receptor antagonists

-names of drugs

Phentolamine (OraVerse), Phenoxybenzamine (Dibenzyline)

13

a1 receptor selective drugs (6)

Prazosin (Minipress), Terazosin (Hytrin), Tamsulosin (flomax), Doxazosin (cardura), Alfuzosin (Uroxatral), Silodosin (Rapaflo)

14

Mixed blockers: two drugs that are Beta and a1 antagonists

Labetalol (Trandate) and Carvedilo (Coreg)

15

B-adrenoceptor blockers

-classes

B1 and B2 blockers, B1 selective

16

B1 and B2 blockers (4)

Propanolol (inderal), Pindolol (visken), Nadolol (corgard), Penbutolol (Levatol)

17

B1 selective blocker (4)

Metoprolol (Toprol), Betaxolol (Kerlone), Acebutolol (Sectral), Atenelol (Tenormin)

18

classes of indirect acting antiadrenergic drugs (2) and examples of those classes

Norepinephrine release inhibitor, inhibitors of tyrosine hydroxylase

NE inhibitor: Guanethidine (Ismelin)

Tyrosine OHase: Metyrosine (Demser)

19

What do adrenomimetics/sympathomimetics do?

mimic or promote the effects of NE, Epi, DA at adrenergic receptors in the sympathetic nervous system

20

Drugs that inhibit adrenergic transmission (sympatholytics or antiadrenergic drugs) prevent what?

prevent the effects of NE/Epi/DA at adrenergic receptors in the sympathetic nervous system

21

a1 type receptors

a1A, a1B, a1D:

-what G protein, what effects?

Gq protein

increase IP3, DAG

22

a2 type receptors

a2A, a2B, a2C

-what G protein, what effects?

Gi protein, decrease cAMP

23

B type receptors

B1, B2, B3

-which G protein, what effects?

Gs protein, increase cAMP

 

24

Dopamine type receptors

D1 and D5:

-which G protein, what effect

Gs protein, increase cAMP

25

Dopamine type receptors

D2, D3, D4:

-which G protein

-what effect

Gi protein, decrease cAMP

26

Steps of a1 receptor activation:

 

-stimulation of receptor by catecholamine leads to activation of a Gq coupling protein

-activated alpha subunit of the G protein activates the effector, phospholipase C

-this causes the release of IP3 and DAG from PtdINs.

-IP3 stimulates release of calcium, leading to increase cytoplasmic Ca

-Ca then can activate Ca dependent protein kinases which phosphorylate their substrates

-DAG activates protein kinase C

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