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Pharm II Old Stuff Final > Adrenergics > Flashcards

Adrenergics Flashcards

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1
Q

Guanfacine

  1. ) Drug class
  2. ) Indication
  3. ) ADR
A
  1. ) Selective α-2 agonist
  2. ) ADHD (hyperactive control)
  3. ) extension of pharmacological profile
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2
Q

Brimonidine

  1. ) Drug class
  2. ) Indication
  3. ) ADR
A
  1. ) Selective α-2 agonist
  2. )eyedrops for glaucoma
  3. ) extension of pharmacological profile
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3
Q

Methyldopa

A
  1. ) Selective α-2 agonist
  2. )FAVORABLE drug for HTN in pregnancy**
  3. ) extension of pharmacological profile
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4
Q

Clonidine

  1. ) Drug class
  2. ) Indication
  3. ) ADR
A
  1. ) Selective α-2 agonist
  2. )HTN**; ADHD; Withdrawal
  3. ) extension of pharmacological profile
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5
Q

α-1 subtypes:

  • 1A?
  • 1B/1D
  • 1D (specifically)

What happens when you antagonize 1A/1D?

A

1A→ Prostate smooth muscle contraction
1B/1D→ vascular smooth muscle contraction
1D→ Bladder neck

Antagonize 1A/1D→ BPH relief (↑ urinary flow)

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6
Q

Arformoterol

1.) Drug class?

A

1.) Selective β -2 Agonist

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7
Q

Indacaterol

1.) Drug class?

A

1.) Selective β -2 Agonist

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8
Q

Atomoxetine

  1. ) Drug class?
  2. ) Indication?
A
  1. ) Indirect sympathomimetic

2. )– Non-stimulant for treatment of ADHD =↑ [NE]

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9
Q

Terazosin

  1. ) Drug class
  2. ) Indication
  3. ) ADR
A
  1. ) Selective α-1 Antagonist
  2. ) HTN and BPH**
  3. ) First dose phenomenon → orthostatic hypotension
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10
Q

Nadolol

  1. ) Drug class?
  2. ) Indications?
A
  1. ) Non-selective β-antagonist
  2. )
    - Glaucoma
    - HTN
    - Migrane prophylaxsis
    - Portal HTN/esophageal varices
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11
Q

Alfuzosin

  1. ) Drug class
  2. ) Indication
  3. ) ADR
A
  1. ) Selective α-1 Antagonist
  2. ) BPH
  3. ) First dose phenomenon → orthostatic hypotension
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12
Q

Labetalol

  1. ) Drug class
  2. ) Indication?
A
  1. ) β-1, β-2, α-1 (ANTAGONIST)

2. ) HTN in pregnancy ***

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13
Q

Metoprolol

1.) Drug class?

A

1.) Selective β -1 Antagonists

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14
Q

Atenolol

1.) Drug class?

A

1.) Selective β -1 Antagonists

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15
Q

Salmeterol

1.) Drug class?

A

1.) Selective β -2 Agonist

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16
Q

Metipranolol

  1. ) Drug class?
  2. ) Indications?
A
  1. ) Non-selective β-antagonist
  2. )
    - Glaucoma
    - HTN
    - Migrane prophylaxsis
    - Portal HTN/esophageal varices
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17
Q

Tizanidine

  1. ) Drug class
  2. ) Indication
  3. ) ADR
A
  1. ) Selective α-2 agonist
  2. )HTN**; ADHD; Withdrawal
  3. ) extension of pharmacological profile
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18
Q

Alfuzosin

  1. ) Drug class
  2. ) Indication
  3. ) ADR
A
  1. ) Selective α-1 Antagonist
  2. ) BPH
  3. ) First dose phenomenon → orthostatic hypotension
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19
Q

Olodaterol

1.) Drug class?

A

1.) Selective β -2 Agonist

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20
Q

Mirabegron

  1. ) Drug class
  2. ) indication
A
  1. ) Selective β-3 agonist (detrusor)

2. ) Overactive bladder → drug will increase bladder capacity during storage phase

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21
Q

Isoproterenol

  1. ) Drug class?
  2. ) Indication?
A
  1. ) Non-selective β-agonist

2. ) for β-1 effect (positive inotrope)

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22
Q

Doxazosin

  1. ) Drug class
  2. ) Indication
  3. ) ADR
A
  1. ) Selective α-1 Antagonist
  2. ) HTN and BPH**
  3. ) First dose phenomenon → orthostatic hypotension
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23
Q

Phenylephrine

  1. ) Drug class
  2. ) Indication
Study These Flashcards
A
  1. )Selective α-1 Agonist
  2. )
    - cold/cough→ weaker sudafed
    - IV vasopressor (↑ BP via vasoconstriction; useful for shock and hypoTN)
    - eyedrops
24
Q

Modafinil

  1. ) Drug class?
  2. ) Indication?
Study These Flashcards
A
  1. ) Indirect sympathetic

2. )treatment for narcolepsy

25
Metaproterenol 1. ) Drug class? 2. ) Indication?
1. ) Non-selective β-agonist | 2. ) for β-2 effect (asthma; COPD)
26
Central Stimulants: Non-Amphetamines 1. ) MOA? 2. ) Agents available?
``` 1.) Similar effect/use as amphetamines but mediated primarily by DA reuptake blockade**** (less NE effects) → less jittery 2.) -Methylphenidate -Dexmethylphenidate ```
27
Midodrine 1. ) Drug class 2. ) Indication
1. ) Selective α-1 Agonist | 2. ) Treatment of orthostatic hypotension
28
Carteolol 1. ) Drug class? 2. ) Indications?
1. ) Non-selective β-antagonist 2. ) - Glaucoma - HTN - Migrane prophylaxsis - Portal HTN/esophageal varices
29
Esmolol | 1.) Drug class?
1.) Selective β -1 Antagonists
30
Dobutamine 1. ) Drug class 2. ) Effect? 3. ) Indication?
1. ) Selective β-1 agonist 2. ) ↑ inotropic effects 3. ) Shock and acute CHF
31
Albuterol/levalbuterol | 1.) Drug class?
1.) Selective β -2 Agonist
32
Betaxolol | 1.) Drug class?
1.) Selective β -1 Antagonists
33
Dexmedetomidine 1. ) Drug class 2. ) Indication 3. ) ADR
1. ) Selective α-2 agonist 2. )IV sedative 3. ) extension of pharmacological profile
34
What three drugs are best for systolic heart failure?
- Carvedilol - Metoprolol - Bisoprolol
35
Bisoprolol | 1.) Drug class?
1.) Selective β -1 Antagonists
36
Prazosin 1. ) Drug class 2. ) Indication 3. ) ADR
1. ) Selective α-1 Antagonist 2. ) HTN and BPH and PTSD nightmares**** 3. ) First dose phenomenon → orthostatic hypotension
37
Pseudoephedrine 1. ) Drug class 2. ) Indication
1. ) Selective α-1 Agonist | 2. ) Nasal decongestant for cough/cold
38
Phenoxybenzamine 1. ) Drug class? 2. ) Indication?
1. ) Non-Selective α-antagonists | 2. ) Pheochromocytoma
39
Acebutolol | 1.) Drug class?
1.) Selective β -1 Antagonists
40
Propranolol 1. ) Drug class? 2. ) Indications?
1. ) Non-selective β-antagonist 2. ) - Glaucoma - HTN - Migrane prophylaxsis - Portal HTN/esophageal varices
41
Carvedilol 1. ) Drug class? 2. ) Indications?
1. ) β-1, β-2, α-1 (ANTAGONIST) | 2. ) Heart failure
42
Levobunolol 1. ) Drug class? 2. ) Indications?
1. ) Non-selective β-antagonist 2. ) - Glaucoma - HTN - Migrane prophylaxsis - Portal HTN/esophageal varices
43
Sotalol 1. ) Drug class? 2. ) Indications?
1. ) Non-selective β-antagonist 2. ) - Glaucoma - HTN - Migrane prophylaxsis - Portal HTN/esophageal varices
44
Formoterol | 1.) Drug class?
1.) Selective β -2 Agonist
45
Tamsulosin 1. ) Drug class 2. ) Indication 3. ) ADR
1. ) Selective α-1 Antagonist 2. ) BPH 3. ) First dose phenomenon → orthostatic hypotension
46
Terbutaline | 1.) Drug class?
1.) Selective β -2 Agonist
47
Inotrope? Chronotrope? Dromotrope?
``` • Inotrope – Contractility (FOC) – Stroke volume (SV) • Chronotrope(SANode) – Heart rate • Dromotrope (AV Node) – Conduction velocity ```
48
Pindolol 1. ) Drug class? 2. ) Indications?
1. ) Non-selective β-antagonist 2. ) - Glaucoma - HTN - Migrane prophylaxsis - Portal HTN/esophageal varices
49
Timolol 1. ) Drug class? 2. ) Indications?
1. ) Non-selective β-antagonist 2. ) - Glaucoma - HTN - Migrane prophylaxsis - Portal HTN/esophageal varices
50
Cocaine 1. ) Drug class? 2. ) therapeutic use?
1. ) Indirect sympathomimetic | 2. ) Topical local anesthesia (sodium channel inhibitor)
51
Oxymetazoline 1. ) Drug class 2. ) Indication
1. ) Selective α-1 Agonist | 2. ) Nasal spray (too much for too long can put hole in nasal passage)
52
Nebivolol | 1.) Drug class?
1.) Selective β -1 Antagonists
53
Central Stimulants: Amphetamines 1. )MOA 2. ) Drugs available?
1. ) Promote release of NE (primarily)*** and DA (at high dose) from pre-synaptic storage into synapse 2. ) Amphetamine;dextroamphetamine(Adderall) -Dextroamphetamine (Dexedrine) - Lisdexamfetamine(Vyvanse) - Methamphetamine(Desoxyn)
54
Silodosin 1. ) Drug class 2. ) Indication 3. ) ADR
1. ) Selective α-1 Antagonist 2. ) BPH*** Most selective to α- 1A receptor 3. ) First dose phenomenon → orthostatic hypotension
55
Oxymetazoline 1. ) Drug class 2. ) Indication
1. ) Selective α-1 Agonist | 2. ) Nasal spray (too much for too long can put hole in nasal passage)
56
Phentolamine 1. ) Drug class? 2. ) Indication?
1.) Non-Selective α-antagonists 2.) Pheochromocytoma

Pharm II Old Stuff Final (19 decks)

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