Adrenoceptors Flashcards
What class of receptor do Adrenoceptors belong to?
They belong to a class of G-protein coupled receptors.
What actions do GPCRs mediate?
GPCRs mediate central and peripheral action of hormones and neurotransmitters NA and A.
How are adrenoceptors used in treating diseases?
The use of agonist and antagonist action help the treatment of diseases.
What are the 3 major types of Adrenoceptors?
Alpha1-adrenoreceptor, Alpha2-adrenoreceptor and Beta-adrenoceptors are the major 3 adrenoceptors.
Where are alpha1-adrenoreceptors expressed and what role do they mediate?
These alpha1-adrenoreceptors are expressed in central and peripheral system post synaptically, mediating a excitatory role.
What G-protein are alpha1-adrenoreceptors coupled to?
What does this enzyme produce?
The G-protein is coupled to phospholipase C and produces IP3 and DAG. (Secondary messengers)
What is the major outcome of the alpha1-adrenoreceptor pathway?
This pathway causes a increase in intracellular calcium ions.
Where are alpha2-adrenoreceptors expressed and what role does this receptors mediate?
They are expressed pre and post synaptically mediating a inhibitor role in the nervous system.
What G-protein are alpha2-adrenoreceptors coupled to and what does this result in?
They are coupled to adenylate cyclase which inhibits the production of cAMP.
What are the three subtypes of beta-adrenoceptors?
Beta1, Beta2 and Beta3 are the subtypes
Where are beta1-adrenoceptors expressed?
These are found in the heart and adipose tissue.
Where are beta2-adrenoceptors expressed?
These are expressed on the vascular, uterine and airway smooth muscles cells.
Beta-adrenoceptors are GPCRs, what is produced by these receptors to mediate a response?
Increased cAMP production mediates the response produced by these receptors.
