ADRs

Question 1

Define ADR

Answer 1

any unintended consequences of drug use, beyond its therapeutic effect.

Question 2

On-target ADRs

Answer 2

exaggerated drug response at the correct site.

Eg Aspirin: may cause GIT bleeding

Question 3

Off-target ADRs

Answer 3

affects unintended target

Eg Aspirin: may cause bronchospasm in asthmatics

Question 4

Aus Classification scheme for ADRs

Answer 4

Augmented
Bizarre
Chronic
Delayed
End of use
Failure

Question 5

Augmented ADRs (common 80%)

Answer 5

Predictable eg bleeding with anticoagulants

Dose - related response, often resolved with reducing dose.

Question 6

3 principal mechanisms for TYPE A

Answer 6

Exaggerated therapeutic response at the target site.
Desired effect but at another site
Impaired Metabolism (drug-drug)