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adverse Flashcards

so many bad things to say about these drugz (69 cards)

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1
Q

adverse

a-methyl-dopa

pro-drug

A 
dizziness
sex dysfx'n
sedation
withdrawal HTN syndrome
autoimmune dysfx'n (Coombs)
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2
Q

adverse

acetylcholine

A 
HTN
GI (diarrhea)
bronchoconstriction
(contra'd asthma)
contra'd heart dz, peptic ulcer, GI
obstruction
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3
Q

adverse

adenosine

A

dyspnea
flushing
hypotension

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4
Q

adverse

albuterol

A

B1 stim at high dose

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5
Q

adverse

amiodarone

A

long Qt > Torsades
pulmonary fibrosis
rhabdomyolysis (w/ simvastatin)

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6
Q

adverse

amlodipine

A

short-acting nifidipine
(cause MI)
contra’d HF

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7
Q

adverse

amphetamine

A

addiction/abuse

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8
Q

adverse

Atenolol

A 
decreased CO
heart block
bradycardia
bronchospasm at high dose
(due to B2 antagonism)
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9
Q

adverse

atorvastatin

A 
contra'd PG, nursing
drug interactions
(gemfibrozil inhibits)
myopathy
rhabdomyolysis
reversible cog fx >50 yo
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10
Q

adverse

atropine

A

tachycardia
urinary retention
glaucoma

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11
Q

adverse

bethanechol

A 
HTN
GI (diarrhea)
bronchoconstriction
(contra'd asthma)
contra'd heart dz, peptic ulcer, GI
obstruction
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12
Q

adverse

botulinum toxin

A

excessive paralysis

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13
Q

adverse

captopril

A 
increase bradykinin levels
(dry cough)
contra'd bilat renal stenosis
contra'd PG
dry cough
tachycardia
lupus
headache
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14
Q

adverse

carbachol

A 
HTN
GI (diarrhea)
bronchoconstriction
(contra'd asthma)
contra'd heart dz, peptic ulcer, GI
obstruction
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15
Q

adverse

carvediLOL

A 
hypotension
bradycardia
bronchospasm
(contra'd in asthma)
decreased CO
heart block
depression
lethargy
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16
Q

adverse

cholestyramine

A 
increase VLDL, TAGs
contra'd hyperTAGemia
GI side effects
rare vit K malabsorption
impedes absorption of drugs
(warfarin, digoxin, thiazides)
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17
Q

adverse

Clonidine

A

dizziness
sex dysfx’n
sedation
withdrawal HTN syndrome

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18
Q

adverse

cocaine

A

addiction, nosey wosey

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19
Q

adverse

digoxin

A 
AV block high dose and with
aldosterone inhibitors
narrow therapeutic index
hyperkalemia
anorexia, nausea, vomit
quinidine and amiodarone increase
cholestyramine reduces
can CAUSE arrhythmia
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20
Q

adverse

diltiazem

A 
constipation
AV block
bradycardia
CHF
contra'd in HF
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21
Q

adverse

Dobutamine

A

angina
chemotrigger nausea
arrhythmia
doesn’t cross to CNS

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22
Q

adverse

dopamine

A

arrhythmia
angina
chemotrigger nausea
does not cross to CNS

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23
Q

adverse

enalaPRIL

A 
dry cough
tachycardia
lupus
headache
renal insufficiency (esp w/ bilateral
renal aa stenosis)
contra'd pregnancy
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24
Q

adverse

ephedrine

A

increase BP

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25
# adverse epinephrine
``` anxiety headache palpitations tremors arrhythmia CVA ```
26
# adverse eplerenONE
hyperkalemia | w/ digoxin can cause AV block
27
# adverse Esmolol
``` decreased CO heart block bradycardia bronchospasm at high dose (due to B2 antagonism) ```
28
# adverse Ezetimibe
no D-D interactions! test liver befor admin low hepatotoxicity
29
# adverse flecainide
ataxia | uncoordination
30
# adverse furosemide
hypokalemia
31
# adverse gemfibrozil
``` inhibits statin absorption potentiates warfarin contra'd in renal/hepatic dz Contra'd PG Contra'd peds GI fx rhabdomyolysis risk with statin ```
32
# adverse Guanethidine
postural HTN sex dysfx'n diarrhea
33
# adverse Hydralazine
Baroreflex | Contra'd CAD, >40yo
34
# adverse hydrochlorothiazide
Contra'd renal dz sexual dysfx'n increase risk arrhythmia
35
# adverse ipratropium
tachycardia urinary retention glaucoma
36
# adverse isoprotenerol
arrhythmia tachycardia palpitations angina
37
# adverse isosorbide dinitrate
hypotension headache contra'd VIAGRA RHF
38
# adverse lidocaine
respiratory arrest | convulsions
39
# adverse losartan
contra'd bilat renal stenosis | contra'd PG
40
# adverse metoprolol
``` Contra'd with Wolff-Parkinson hypotension bradycardia bronchospasm contra'd in asthma ```
41
# adverse mexiletine
respiratory arrest | convulsions
42
# adverse Minoxidil
Baroreflex | Contra'd CAD
43
# adverse niacin
``` Cutaneous flushing vasodilation (take aspirin) hepatotoxicity Gi fx (contra'd peptic dz) Contra'd PG ```
44
# adverse nifedipine
``` constipation AV block bradycardia CHF contra'd in HF ```
45
# adverse nimodipine
``` constipation AV block bradycardia CHF contra'd in HF ```
46
# adverse NITroglycerin
hypotension headache contra'd VIAGRA RHF
47
# adverse norepinephrine
``` anxiety headache palpitations tremors arrhythmia CVA ```
48
# adverse phentolamine
^^tachycardia (reflex + increased NE at B1 receptors)
49
# adverse phenylephrine
increase BP
50
# adverse phenyloxybenzamine
reflex tachycardia orthostatic HTN sex dysfx'n congestion
51
# adverse pravastatin
no D-D interactions! | otherwise same fx
52
# adverse Prazosin
``` "1st dose phenom" Na retention reflex tachycardia orthostatic HTN sex dysfx'n congestion ```
53
# adverse procainamide
``` slowing aFib SA might raise AV and cause vTac Asystole w/ AV block Long QT syndrome, Torsades fever, diarrhea, lupus-ish ```
54
# adverse Propanolol
``` HoTN decreased CO heart block bradycardia bronchoconstriction (B2) contra'd asthma depression lethargy ED insomnia ```
55
# adverse quinidine
``` slowing aFib SA might raise AV and cause vTac Asystole w/ AV block Long QT syndrome, Torsades fever, diarrhea, lupus-ish ```
56
# adverse Reserpine
sedation impaired concentration depression orthostatic HTN
57
# adverse sarin gas
``` bioterror!!! SLUDGE resp paralysis convulsions coma ataxia ```
58
# adverse Sodium nitroprusside
Contra'd Viagra
59
# adverse sotalol
long Qt > Torsades | rhabdomyolysis (w/ simvastatin)
60
# adverse sprinolactONE
hyperkalemia | w/ digoxin can cause AV block
61
# adverse succinylcholine
``` muscle fasciculations contra'd: atypical Ach-erase hyperthermia hyperkalema (arrhythmias) contra'd renal dysfx'n, burn pts ```
62
# adverse terbutaline
B1 stim at high dose
63
# adverse thiazide
hypokalemia
64
# adverse Timolol
``` decreased CO heart block bradycardia bronchoconstriction (B2) contra'd asthma depression lethargy ```
65
# adverse tubocurarine
contra'd aminoglycosides contra'd inhalation anesthetics HTN histamin release
66
# adverse tyramine
Contra'd w/ MAOIs
67
# adverse varenicline | Chantix
neuropsychiatric sx suicide depression
68
# adverse vecuronium
contra'd aminoglycosides contra'd inhalation anesthetics HTN histamin release
69
# adverse verapamil
``` constipation AV block bradycardia CHF contra'd in HF ```

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