Adverse Drug Interactions

Question 1

Gentamicin/Vancomycin

Answer 1

Nephrotoxicity

Ototoxicity

Question 2

Any antibiotic

Answer 2

Clostridium difficile colitis

Question 3

ACEi

Answer 3

Hypotension
Electrolyte abnormalities
Acute Kidney Injury
Dry Cough

Question 4

Beta-Blockers

Answer 4

Hypotension
Bradycardia
Wheeze (asthmatics)
Worsens acute Hf

Question 5

Calcium Channel Blockers

Answer 5

Hypotension
Bradycardia
Peripheral Oedema
Flushing

Question 6

Diuretics

Answer 6

Hypotension
Electrolyte abnormalities
Acute Kidney Injury

Question 7

Heparin

Answer 7

Haemorrhage

Heparin-induced thrombocytopenia

Question 8

Warfarin

Answer 8

Haemorrhage

Question 9

Aspirin

Answer 9

Haemorrhage
Peptic Ulcers and gastritis
Tinnitus in large doses

Question 10

Digoxin

Answer 10

Nausea, Vomiting and Diarrhoea
Blurred vision
Confusion and drowsiness
Xanthopsia

Question 11

Amiodarone

Answer 11

Interstitial Lung Disease (pulmonary fibrosis)
Thyroid disease
Skin greying
Corneal deposits

Question 12

Lithium

Answer 12

Eary: tremor
Intermediate: tiredness
Late: arrhythmias, seizures, coma, renal failure, diabetes insipidus

Question 13

Haloperidol

Answer 13

Dyskinesias e.g. acute dystonic reaction, drowsiness

Question 14

Clozapine

Answer 14

Agranulocytosis

Question 15

Dexamethasone and prednisolone

Answer 15

Stomach Ulcers
Thin skin
Edema
Right and left heart failure
Osteoporosis
Infection e.g. candida
Diabetes 
Cushings Syndrome

Question 16

Fludrocortisone

Answer 16

Hypertension

Sodium and water retention

Question 17

Ibuprofen

Answer 17

No urine
Systolic dysfunction
Asthma
Indigestion
Dyscrasia

Question 18

Simvastatin

Answer 18

Myalgia
Abdominal pain
Increased AST/ALT
Rhabomyolysis

Reduce the dose
Switch to another statin

Question 19

Metformin

Answer 19

Lactic Acidosis

Question 20

Monoamine Oxidase Inhibitors

Answer 20

Hypertensive Crisis

Question 21

Metronidazole

Answer 21

sweating
Flushing
nausea and vomiting