Adverse Drug Reactions Flashcards
(24 cards)
Which drugs cause C.diff
co-amox
clindalmycin
ciprofloxacin
cephalosporins (ceftriaxone, cefalexin)
Drugs causing ototoxicity
furosemide (if IV or renal impair), gentamicin, vancomycin, bumetanide
methotrexate + NSAIDs
low platelets
methotrexate + trimethoprim
bone marrow suppression
methotrexate + PPI
increase conc of methotrexate
precipitants of C.diff?
PPI
low Mg
low Na
what interacts with statins to cause muscle pain
clarithromycin
Inducers
CARbamazepine, barbituates, phenytoin, rifampicin, pioglitazone
effect of PPI on CYP450
inhibitor - use lanzoprazole when patient on clopidogrel
CYP450 inhibitors
omeprazole, amiodarone, SSRI, izoniazid, cimetidine, macrolides, SSRI, grapefruit
how do you treat anti-psychotic induced parkinsonism
procyclidine hydrochloride
drugs causing parkinsonism
haloperidol
signs of serotonin syndrome
abrupt onset, myoclonus, tremor, hyperreflexia, BIG PUPILS MYDRIASS
signs of neuroleptic malignant syndrome
gradual onset, prolonged duration, rigidity, hyporeflexia, normal pupils
causes of neuroleptic malignant syndrome
antipsychotics (diffuse rigidity with decreae reflexes)
how do you treat neuroleptic malignant syndrome
bromocriptin and dantrolene
side effects of chlorpromazine, haloperidol
acute dystonia (sustained muscle contraction)
akathiasia (restlessness)
tardive dyskinesia (facial grimace, lip smacking)
atypical antipsychotic examples
quetiapine, olanzapine
side effects on atypical antipsychotics
weight gain, diabetes, rise in lipids
all antipsychotics can cause what
extrapyramidal symptoms (tremor, involuntary muscle contraction)
which two drugs can increase risk of tendon rupture (achilles, elbow)
ciprofloxacin (quinolones) and steroids
side effects of quinolones
tendonitis, QT prolongation, reduced seizure threshold
if amlodipine causing ankle swelling what should you do
STOP amlodipine not reduce
when do you stop metformin in renal impairment
eGFR <30
